1型糖尿病青少年使用他汀类药物的风险与益处
Risks and benefits of statin use in young people with type 1 diabetes.
作者信息
Bjornstad Petter, Wadwa R Paul
机构信息
Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
出版信息
Curr Diab Rep. 2014 Jul;14(7):499. doi: 10.1007/s11892-014-0499-8.
Abstract
Cardiovascular disease (CVD) is the primary cause of mortality in patients with type 1 diabetes (T1D). Despite advances in the management of microvascular complications of T1D, there is a lack of similar progress in reduction of macrovascular complications. Dyslipidemia is one of the major contributory factors for macrovascular complications in T1D, but the literature suggests significant under-treatment of this risk factor in children and adolescents with diabetes. Statins have shown to be both effective and safe in young people with familial hypercholesterolemia and adults with diabetes mellitus, but the role for statins in children and adolescent with T1D remains unclear and controversial. In this review, we will summarize the risks and benefits of statin use in young people with T1D.
摘要
心血管疾病（CVD）是1型糖尿病（T1D）患者死亡的主要原因。尽管在T1D微血管并发症的管理方面取得了进展，但在减少大血管并发症方面缺乏类似的进展。血脂异常是T1D大血管并发症的主要促成因素之一，但文献表明，糖尿病儿童和青少年中该危险因素的治疗明显不足。他汀类药物已被证明对患有家族性高胆固醇血症的年轻人和患有糖尿病的成年人既有效又安全，但他汀类药物在患有T1D的儿童和青少年中的作用仍不明确且存在争议。在本综述中，我们将总结他汀类药物在患有T1D的年轻人中使用的风险和益处。
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