从(+)-喇叭茶醇合成贝壳杉烷二萜类化合物加拉纳尔 A 和 B。

Synthesis of labdane diterpenes galanal A and B from (+)-sclareolide.

机构信息

Institute of Chemistry, Academia Sinica , Nankang, Taipei 11529, Taiwan.

出版信息

Org Lett. 2014 Jun 6;16(11):2990-2. doi: 10.1021/ol501121v. Epub 2014 May 5.

Abstract

The first chemical synthesis of galanal A and B was achieved by a concise and highly efficient pathway starting from commercially available (+)-sclareolide and features a Wittig reaction and a titanocene-mediated radical cyclization as the key steps.

摘要

Galanal A 和 B 的首次全合成是通过一条简洁高效的路线实现的，该路线以商业可得的(+)-喇叭醇为起始原料，关键步骤为Wittig 反应和钛介导的自由基环化。