Chong Pee-Win, Beah Zhi-Ming, Grube Barbara, Riede Linda
InQpharm Europe Ltd, Invision House, Wilbury Way, Hitchin, Hertfordshire, SG4 0TY, UK.
Phytother Res. 2014 Oct;28(10):1520-6. doi: 10.1002/ptr.5158. Epub 2014 May 2.
IQP-GC-101 is a patented blend of the standardized extracts of Garcinia cambogia, Camellia sinensis, unroasted Coffea arabica, and Lagerstroemia speciosa. These individual ingredients of IQP-GC-101 have each shown promise in promoting weight loss; however, the efficacy of the blend has not been established. This randomized, placebo-controlled, double-blind, parallel group study conducted over 14 weeks (including a 2-week run-in phase) aimed to investigate the efficacy and safety of IQP-GC-101 in reducing body weight and body fat mass in overweight Caucasian adults. Subjects took three IQP-GC-101 or placebo tablets, twice a day, 30 min before main meals. All subjects also adhered to a 500 kcal/day energy deficit diet with 30% of energy from fat. Ninety-one overweight and mildly obese subjects (46 in the IQP-GC-101 group, 45 in the placebo group) completed the study. After 12-week intervention, IQP-GC-101 resulted in a mean (±SD) weight loss of 2.26 ± 2.37 kg compared with 0.56 ± 2.34 kg for placebo (pU = 0.002). There was also significantly more reduction in body fat mass, waist circumference, and hip circumference in the IQP-GC-101 group. No serious adverse events were reported. The use of IQP-GC-101 has been shown to result in body weight and body fat reduction in the current study, with good tolerability.
IQP-GC-101是一种专利配方，由藤黄果、绿茶、未烘焙的阿拉比卡咖啡豆和柳叶紫薇的标准化提取物混合而成。IQP-GC-101的这些单一成分在促进减肥方面均显示出前景；然而，该配方的功效尚未得到证实。这项随机、安慰剂对照、双盲、平行组研究历时14周（包括2周的导入期），旨在调查IQP-GC-101在减轻超重白人成年人的体重和体脂方面的功效和安全性。受试者在主餐前三十分每天服用三次IQP-GC-101或安慰剂片剂。所有受试者还坚持每天500千卡的能量赤字饮食，其中30%的能量来自脂肪。91名超重和轻度肥胖受试者（IQP-GC-101组46名，安慰剂组45名）完成了研究。经过12周的干预，IQP-GC-101组的平均（±标准差）体重减轻了2.26±2.37千克，而安慰剂组为0.56±2.34千克（pU = 0.002）。IQP-GC-101组的体脂量、腰围和臀围也有更显著的减少。未报告严重不良事件。在当前研究中，使用IQP-GC-101已显示出可减轻体重和体脂，且耐受性良好。
