Kudiganti Venkateshwarlu, Kodur Raveendra Ramamurthy, Kodur Sushma Raveendra, Halemane Manjunath, Deep Dheeraj Kumar
Srinivasa clinic and Diabetic care center, Girinagar, BSK 3rd Stage, Bengaluru, 560 085, Karnataka, India.
D2L Clinical Solutions, Bengaluru, 560048, India.
Lipids Health Dis. 2016 Aug 24;15(1):136. doi: 10.1186/s12944-016-0306-4.
Meratrim is a blend of two plant extracts obtained from Sphaeranthus indicus flower heads and Garcinia mangostana fruit rinds. Previous studies have demonstrated that Meratrim is effective for weight management in obese individuals. The objective of this study was to assess the efficacy and tolerability of Meratrim in managing body weight in healthy overweight subjects.
Sixty participants with a mean BMI of 28.3 kg/m(2) were randomized into two groups receiving either 400 mg of Meratrim twice daily or two identical placebo capsules for a period of 16 weeks. Subjects were asked to consume about 2,000 kcal/day throughout the study period and walk 5 days a week for 30 min daily. The primary endpoint was defined as the change in body weight from baseline to end of week 16 for the Meratrim group versus placebo. Fifty seven subjects completed the trial.
At study conclusion, statistically significant reductions in body weight (5.09 vs. 1.1 kg; p < 0.0001), BMI (1.91 vs. 0.43 kg/m(2); p < 0.0001), waist (9.97 vs. 3.71 cm; p < 0.001) and hip size (10.38 vs. 5.11 cm; p < 0.0001) were observed in the Meratrim versus the placebo group. Additionally, a significant change in serum LDL (-14.79 vs. 6.25 mg/dL; p < 0.0001), triglycerides (-43.62 vs. -13.68 mg/dL; p < 0.001) and total cholesterol (-20.0 vs. -0.75 mg/dL; p = 0.0002) was observed in the Meratrim cohort compared to the placebo. No supplementation related adverse events were noted during the study.
The study findings suggest that Meratrim is well-tolerated and is an effective ingredient for weight management in healthy overweight subjects.
CTRI/2014/07/004727; www.CTRI.nic.in.
Meratrim是一种由两种植物提取物混合而成的产品，这两种提取物分别取自印度圆叶薄荷的头状花序和山竹的果皮。先前的研究表明，Meratrim对肥胖个体的体重管理有效。本研究的目的是评估Meratrim对健康超重受试者体重管理的疗效和耐受性。
60名平均BMI为28.3kg/m²的参与者被随机分为两组，一组每天服用两次400mg的Meratrim，另一组服用两颗相同的安慰剂胶囊，为期16周。在整个研究期间，受试者被要求每天摄入约2000千卡热量，每周步行5天，每天步行30分钟。主要终点定义为Meratrim组与安慰剂组从基线到第16周结束时体重的变化。57名受试者完成了试验。
在研究结束时，与安慰剂组相比，Meratrim组的体重（5.09 vs. 1.1kg；p＜0.0001）、BMI（1.91 vs. 0.43kg/m²；p＜0.0001）、腰围（9.97 vs. 3.71cm；p＜0.001）和臀围（10.38 vs. 5.11cm；p＜0.0001）在统计学上有显著降低。此外，与安慰剂相比，Meratrim组的血清低密度脂蛋白（-14.79 vs. 6.25mg/dL；p＜0.0001）、甘油三酯（-43.62 vs. -13.68mg/dL；p＜0.001）和总胆固醇（-20.0 vs. -0.75mg/dL；p = 0.0002）有显著变化。在研究期间未发现与补充剂相关的不良事件。
研究结果表明，Meratrim耐受性良好，是健康超重受试者体重管理中的一种有效成分。
CTRI/2014/07/004727；www.CTRI.nic.in。
