Habenicht U F, el Etreby M F, Lewis R, Ghoniem G, Roberts J
Research Laboratories of Schering AG and Bergkamen, Berlin (West), Federal Republic of Germany.
J Urol. 1989 Dec;142(6):1624-6. doi: 10.1016/s0022-5347(17)39181-4.
Metachromasia has been shown to be a stromal marker for human benign prostatic hyperplasia (BPH). So far, it is not known whether comparable changes can be demonstrated in experimentally induced BPH in the dog or in a subhuman primate species. In the present study, the phenomenon of metachromasia could be demonstrated in the prostate of cynomolgus monkeys, too. The reaction was quantitatively intensified by the treatment with androstenedione--an aromatizable androgen which caused hyperplastic and hypertrophic changes--especially a stimulation of the smooth muscle--in the stroma of the prostate. Simultaneous treatment with the aromatase inhibitor 1-methyl-ADD prevented both the phenomenon of metachromasia and the stimulation of the stroma. In conclusion, it is not only possible to induce hyperplastic/hypertrophic changes in the prostate of a subhuman species by means of an aromatizable androgen but, in addition, this effect is accompanied by a phenomenon which is thought to be typical for human BPH suggesting the suitability of this type of experiment for the study of the factors involved in the pathogenesis of BPH.
异染性已被证明是人类良性前列腺增生（BPH）的一种基质标志物。到目前为止，尚不清楚在实验诱导的犬或非人灵长类动物的BPH中是否能观察到类似变化。在本研究中，食蟹猴前列腺中也能证实异染性现象。用雄烯二酮（一种可芳香化的雄激素，可引起前列腺基质增生和肥大性变化，尤其是平滑肌的刺激）处理后，反应在数量上增强。同时用芳香化酶抑制剂1-甲基-ADD处理可防止异染性现象和基质刺激。总之，不仅可以通过可芳香化的雄激素在非人灵长类动物前列腺中诱导增生/肥大性变化，而且这种效应还伴随着一种被认为是人类BPH典型的现象，表明这类实验适用于研究BPH发病机制中的相关因素。
