Habenicht U F, el Etreby M F
Research Laboratories of Schering AG, Berlin (West), Federal Republic of Germany.
Prostate. 1989;14(4):309-22. doi: 10.1002/pros.2990140404.
Interference with estrogenic and androgenic actions might result in an inhibitory effect of benign prostatic hyperplasia (BPH). In the present study the effects of the treatment of intact, adult beagle dogs with the antiandrogen cyproterone acetate (CPA) and the aromatase inhibitor 1-methyl-ADD either alone or in combination on androstenedione-induced prostate growth and on testes, epididymides, and the pituitary was investigated. 1-Methyl-ADD induced a marked counterregulatory increase in the serum testosterone and dihydrotestosterone (DHT) concentrations leading to hyperplasia of the glandular part of the prostate. However, the aromatase inhibitor antagonized the androstenedione-induced (estrogen-related) stimulation of the fibromuscular stroma of the prostate. CPA caused a complete atrophy of the prostate that was also present after treatment with both the aromatase inhibitor and CPA in spite of a striking elevation of the serum testosterone and DHT levels and in spite of the antagonization of the inhibition of testes and epididymal weight induced by androstenedione plus CPA. This indicates a selective inhibition of the prostate of intact beagle dogs treated with CPA and 1-methyl-ADD.
干扰雌激素和雄激素作用可能会对良性前列腺增生（BPH）产生抑制作用。在本研究中，研究了单独或联合使用抗雄激素醋酸环丙孕酮（CPA）和芳香化酶抑制剂1-甲基-ADD对成年雄性比格犬进行处理，对雄烯二酮诱导的前列腺生长以及对睾丸、附睾和垂体的影响。1-甲基-ADD导致血清睾酮和双氢睾酮（DHT）浓度显著的代偿性升高，从而导致前列腺腺泡部分增生。然而，芳香化酶抑制剂拮抗了雄烯二酮诱导的（与雌激素相关的）前列腺纤维肌肉基质的刺激。CPA导致前列腺完全萎缩，在用芳香化酶抑制剂和CPA联合治疗后，尽管血清睾酮和DHT水平显著升高，尽管拮抗了雄烯二酮加CPA诱导的睾丸和附睾重量的抑制，但这种萎缩仍然存在。这表明CPA和1-甲基-ADD处理的成年雄性比格犬的前列腺受到了选择性抑制。
