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异烟肼所致脱发。

Alopecia caused by isoniazid.

作者信息

Dixit Ramakant, Qureshi Danish, Mathur Sunil

机构信息

Departments of Respiratory Medicine and Pharmacology and Experimental Therapeutics, J. L. N. Medical College, Ajmer, Rajasthan, India.

出版信息

J Pharmacol Pharmacother. 2014 Apr;5(2):155-7. doi: 10.4103/0976-500X.130081.

DOI:10.4103/0976-500X.130081
PMID:24799819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4008914/
Abstract

Drug-induced alopecia is a known clinical entity and mainly seen with anti-mitotic drug therapy. Alopecia during anti-tuberculosis therapy is very uncommon and previously observed with isoniazid, thiacetazone, and ethionamide. Present communication describes an additional case of isoniazid-induced alopecia in a 10-year-old male child, which was reversible after isoniazid withdrawal. Possible mechanisms of drug-induced alopecia are also briefly discussed.

摘要

药物性脱发是一种已知的临床病症，主要见于抗有丝分裂药物治疗。抗结核治疗期间的脱发非常罕见，之前曾观察到异烟肼、硫乙酰胺和乙硫异烟胺可导致脱发。本文报道了一例10岁男性儿童因异烟肼导致脱发的病例，停用异烟肼后脱发情况可逆。文中还简要讨论了药物性脱发的可能机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9292/4008914/0e78a1733890/JPP-5-155-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9292/4008914/0e78a1733890/JPP-5-155-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9292/4008914/0e78a1733890/JPP-5-155-g001.jpg

相似文献

1
Alopecia caused by isoniazid.异烟肼所致脱发。
J Pharmacol Pharmacother. 2014 Apr;5(2):155-7. doi: 10.4103/0976-500X.130081.
2
Isoniazid-induced alopecia.异烟肼所致脱发。
Lung India. 2011 Jan;28(1):60-1. doi: 10.4103/0970-2113.76304.
3
[Comparative study of 2 types of oral therapy of pulmonary tuberculosis (ethionamide and isoniazid, thiacetazone and isoniazid)].两种肺结核口服疗法（乙硫异烟胺与异烟肼、氨硫脲与异烟肼）的对比研究
Bull World Health Organ. 1968;39(5):731-69.
4
Chromosome-damaging action of isoniazid and thiacetazone on human lymphocyte cultures in vivo.异烟肼和氨硫脲对人体淋巴细胞培养物的体内染色体损伤作用。
Hum Genet. 1981;57(3):321-2. doi: 10.1007/BF00278953.
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A katG S315T or an ahpC promoter mutation mediate Mycobacterium tuberculosis resistance to 2-thiophen carboxylic acid hydrazide, an inhibitor resembling the anti-tubercular drugs Isoniazid and Ethionamide.katG S315T突变或ahpC启动子突变介导结核分枝杆菌对2-噻吩羧酸酰肼耐药，2-噻吩羧酸酰肼是一种类似于抗结核药物异烟肼和乙硫异烟胺的抑制剂。
Tuberculosis (Edinb). 2018 Sep;112:69-78. doi: 10.1016/j.tube.2018.08.001. Epub 2018 Aug 3.
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[CLINICAL TRIAL OF 3 TYPES OF ORAL TREATMENT OF PULMONARY TUBERCULOSIS. (ISONIAZID+ETHIONAMIDE, ISONIAZID + PAS, ISONIAZID ALONE)].[三种口服治疗肺结核方法的临床试验。（异烟肼+乙硫异烟胺、异烟肼+对氨基水杨酸、单用异烟肼）]
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[TREATMENT OF PRIMARY TUBERCULOUS INFECTION OF THE INFANT WITH RECTAL ETHIONAMIDE IN ASSOCIATION WITH ORAL ISONIAZID].[直肠用乙硫异烟胺联合口服异烟肼治疗婴儿原发性结核感染]
Arch Fr Pediatr. 1965 Jan;22:118-22.
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Randomised trial of thiacetazone and rifampicin-containing regimens for pulmonary tuberculosis in HIV-infected Ugandans. The Makerere University-Case Western University Research Collaboration.含氨硫脲和利福平方案治疗乌干达HIV感染患者肺结核的随机试验。马凯雷雷大学与凯斯西储大学研究合作项目。
Lancet. 1994 Nov 12;344(8933):1323-8. doi: 10.1016/s0140-6736(94)90693-9.
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[Cutaneous reactions to thiacetazone (TB1) (author's transl)].对氨硫脲（TB1）的皮肤反应（作者译）
Rev Fr Mal Respir. 1979 Sep-Oct;7(5):467-70.
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[Cross-resistance between isoniazid and ethionamide and its strong association with mutation C-15T in Mycobacterium tuberculosis isolates from Peru].[秘鲁结核分枝杆菌分离株中异烟肼与乙硫异烟胺之间的交叉耐药性及其与C-15T突变的强关联]
Rev Argent Microbiol. 2020 Jan-Mar;52(1):36-42. doi: 10.1016/j.ram.2019.03.005. Epub 2019 Jun 27.

本文引用的文献

1
Ethionamide-induced gynecomastia.乙硫异烟胺所致男性乳房发育症。
J Pharmacol Pharmacother. 2012 Apr;3(2):196-9. doi: 10.4103/0976-500X.95532.
2
Cicatricial (scarring) alopecias: an overview of pathogenesis, classification, diagnosis, and treatment.瘢痕性（瘢痕性）脱发：发病机制、分类、诊断和治疗概述。
Am J Clin Dermatol. 2012 Aug 1;13(4):247-60. doi: 10.2165/11596960-000000000-00000.
3
Isoniazid-induced alopecia.异烟肼所致脱发。
Lung India. 2011 Jan;28(1):60-1. doi: 10.4103/0970-2113.76304.
4
Alopecia in association with lamotrigine use: an analysis of individual case safety reports in a global database.与拉莫三嗪使用相关的脱发：全球数据库中个体病例安全报告的分析。
Drug Saf. 2010 Aug 1;33(8):653-8. doi: 10.2165/11536190-000000000-00000.
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Molecular mechanisms of chemotherapy-induced hair loss.化疗导致脱发的分子机制。
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Isonicotinic acid hydrazide induced anagen effluvium and associated lichenoid eruption.异烟肼诱发生长期脱发及相关苔藓样疹。
J Dermatol. 2001 Dec;28(12):737-41.
7
Overexpression of Bcl-2 protects from ultraviolet B-induced apoptosis but promotes hair follicle regression and chemotherapy-induced alopecia.Bcl-2的过表达可保护细胞免受紫外线B诱导的凋亡，但会促进毛囊退化和化疗诱导的脱发。
Am J Pathol. 2000 Apr;156(4):1395-405. doi: 10.1016/S0002-9440(10)65008-0.
8
Alopecia side-effect of antituberculosis drugs.抗结核药物的脱发副作用。
Lancet. 1996 Feb 17;347(8999):472. doi: 10.1016/s0140-6736(96)90048-3.
9
Drug-induced hair loss and hair growth. Incidence, management and avoidance.药物性脱发与毛发生长。发生率、管理与预防
Drug Saf. 1994 Apr;10(4):310-7. doi: 10.2165/00002018-199410040-00005.
10
[Drug-induced alopecia: review of the literature].
Therapie. 1995 Mar-Apr;50(2):145-50.