Bordes M, Brunet-Lecomte P, Dusserre P, Dusserre-Guion L, Michiels-Marzais D, Morlevat F, Peny J, Roignot P, Colas J M, Ferry N
Laboratoire de Pathologie Humaine et Expérimentale, Dijon.
Ann Urol (Paris). 1989;23(4):295-300.
Prostate specific antigen (PSA) is a prostate tissue marker detected by immunostaining in 97% of specimens examined. Tissue staining is variable and cancers are more heterogeneous than normal or hyperplastic prostate. Serum PSA levels in patients with normal or hyperplastic lesions are 12 ng/ml + 19 and are positively correlated with the weight of the gland. In patients with carcinoma serum PSA levels are 216 ng/ml + 782 and are positively correlated with tumor spread. PSA assay is of little value for screening for prostatic carcinoma. However, carcinoma of prostate is more frequent when PSA levels are above 10 ng/ml and the level of 50 ng/ml indicates capsular penetration, seminal vesicle or lymph node involvement or metastatic spread.
前列腺特异性抗原（PSA）是一种前列腺组织标志物，在97%的检测标本中可通过免疫染色检测到。组织染色存在差异，癌症比正常或增生性前列腺组织更加异质性。正常或增生性病变患者的血清PSA水平为12 ng/ml ± 19，且与腺体重量呈正相关。癌患者的血清PSA水平为216 ng/ml ± 782，且与肿瘤扩散呈正相关。PSA检测对前列腺癌筛查价值不大。然而，当PSA水平高于10 ng/ml时前列腺癌更为常见，50 ng/ml的水平表明有包膜侵犯、精囊或淋巴结受累或转移扩散。
