成人神经发生：机制和功能意义。

Adult neurogenesis: mechanisms and functional significance.

机构信息

Brain Research Institute, Faculty of Medicine and Science, University of Zurich, 8057 Zurich, Switzerland.

出版信息

Development. 2014 May;141(10):1983-6. doi: 10.1242/dev.104596.

Abstract

New neurons are generated throughout life in distinct regions of the mammalian brain. This process, called adult neurogenesis, has been implicated in physiological brain function, and failing or altered neurogenesis has been associated with a number of neuropsychiatric diseases. Here, we provide an overview of the mechanisms governing the neurogenic process in the adult brain and describe how new neurons may contribute to brain function in health and disease.

摘要

新的神经元在哺乳动物大脑的不同区域中一生都在生成。这一过程被称为成年神经发生，它与大脑的生理功能有关，而神经发生的失败或改变与许多神经精神疾病有关。在这里，我们概述了控制成年大脑神经发生过程的机制，并描述了新神经元如何在健康和疾病状态下为大脑功能做出贡献。