Schröder R, Schorre W, Rath I
Fortschr Neurol Psychiatr Grenzgeb. 1978 May;46(5):231-47.
The idiopathic orthostatic hypotension can be characterized as a presenile degenerative process with a liability to attack especially multiple systems. In the course of the disease clinically the autonomic functional failure stands in the beginning. It also determines the serious illness in the later stages, which is associated with an additional variable neurologic syndrome. By means of an own clinically and pathologically examined case it is given a survey of the present knowledge about the disease process. Especially it is declared on the localization of the lesions. Phaemacological tests point to a main disturbance of the preganglionic respectively central part of the sympathetic system. The analysis of the neuropathologically examined cases shows as the most regular finding a neuronal loss in the nucleus intermediolateralis, which certainly is hold responsible for a great part of the functional failure. But it is to assume, that lesions in other structures cooperate in the genesis of the syndrome, which morphologically are not yet recorded.
特发性直立性低血压可被描述为一种早老性退行性过程，易侵袭多个系统。在疾病过程中，临床上自主神经功能衰竭在初期就已存在。它也决定了后期的严重病情，这与额外的可变神经综合征相关。通过一个自己临床和病理检查的病例，对目前关于疾病过程的知识进行了综述。特别阐述了病变的定位。药理学测试表明交感神经系统节前或中枢部分存在主要障碍。对神经病理学检查病例的分析显示，最常见的发现是中间外侧核的神经元丢失，这无疑是导致大部分功能衰竭的原因。但可以推测，其他结构的病变在该综合征的发生中也起作用，只是在形态学上尚未被记录。
