Periti E, Cariati E, Brizzi L, Nannini R, Paladini S
J Nucl Med Allied Sci. 1989 Jul-Sep;33(3 Suppl):81-4.
The limit of the classic diagnostic protocols following the evidence of high maternal serum alpha-fetoprotein levels is represented by the high number of amniocenteses performed and that, in the most part of cases, give false negative results. Now days the introduction of high resolution ecographic equipments allows to us, in many cases, to clarify the diagnostic without further examinations. The Authors propose a diagnostic protocol that include the execution of high resolution ultrasound at the second withdrawal of serum alpha-fetoprotein, limiting the use of amniocentesis only when is necessary to determine the fetal karyotype. An high sensibility diagnostic system with a favourable cost/benefit ratio results from this approach.
经典诊断方案在孕妇血清甲胎蛋白水平升高证据下的局限性表现为进行羊膜穿刺术的次数众多，且在大多数情况下，羊膜穿刺术会给出假阴性结果。如今，高分辨率超声设备的引入使我们在许多情况下无需进一步检查就能明确诊断。作者提出了一种诊断方案，该方案包括在第二次检测血清甲胎蛋白时进行高分辨率超声检查，仅在需要确定胎儿核型时才限制使用羊膜穿刺术。这种方法产生了一种高灵敏度且成本效益比良好的诊断系统。
