Strigini F, Melis G B, Gasperini M, Fioretti P
J Nucl Med Allied Sci. 1989 Jul-Sep;33(3 Suppl):77-80.
With the aim of evaluating the clinical value of raised maternal plasma alpha-fetoprotein (AFP) in women with singleton fetuses without structural abnormalities, the outcome of pregnancy was evaluated in a group of 20 women with these characteristics. Only 6 women (30%) delivered fetuses with appropriate birthweight at term; there were 6 pregnancy losses (30%), and the remaining pregnancies ended in pre-term delivery and/or birth of a small for gestational age fetus. Ultrasound examination supplied additional information in 3 cases only. Amniocentesis did not seem to affect pregnancy outcome in this group of high-risk pregnancies. Serial AFP testing was useless for monitoring these pregnancies. It is concluded that raised maternal plasma AFP must be regarded as a marker of poor pregnancy outcome even after exclusion of neural tube defects.
为了评估单胎妊娠且胎儿无结构异常的孕妇血浆甲胎蛋白（AFP）升高的临床价值，对一组具有这些特征的20名孕妇的妊娠结局进行了评估。只有6名妇女（30%）足月分娩出出生体重适宜的胎儿；有6例妊娠丢失（30%），其余妊娠以早产和/或小于胎龄儿出生告终。超声检查仅在3例中提供了额外信息。在这组高危妊娠中，羊膜穿刺术似乎并未影响妊娠结局。连续AFP检测对监测这些妊娠并无用处。得出的结论是，即使排除神经管缺陷后，孕妇血浆AFP升高也必须被视为不良妊娠结局的一个标志物。
