Sichletidis Lazaros, Spyratos Dionisios, Tsiotsios Anastasios, Haidich Anna-Bettina, Ganidis Ioannis, Michailidis Dimitrios, Triantafyllou Georgios, Kottakis George, Melas Dimitrios
Int J Occup Environ Health. 2014 Jan-Mar;20(1):9-15. doi: 10.1179/2049396713Y.0000000047.
To investigate whether air pollution is a potential risk factor for airways obstruction.
A prospective cohort study (11.3 +/- 2.9 years) that took place in two areas (Eordea where concentration of PM10 was high and Grevena, Greece). We used the MRC questionnaire, spirometry, and anterior rhinomanometry at both visits.
Initially we examined 3046 subjects. After excluding chronic obstructive pulmonary disease (COPD) patients, we re-examined 872 subjects and 168 of them had developed COPD (Grevena: 24.3%, Eordea: 18.5%). Multivariable logistic regression analysis showed that the area of residence and thus exposure to air pollution was not a risk factor for the development of COPD (OR: 0.51, 95% CI: 0.18-1.46, P = 0.21). On the other hand, residence in Eordea was strongly related to the development of severe nasal obstruction (OR: 11.47, 95% CI: 6.15-21.40, P < 0.001). Similar results were found after excluding patients with COPD stage I as well as in the subgroup of never smokers.
Air pollution was associated with severe nasal obstruction but not with COPD development.
研究空气污染是否为气道阻塞的潜在危险因素。
在两个地区（希腊的埃奥雷亚，PM10浓度高；格雷韦纳）进行了一项前瞻性队列研究（11.3±2.9岁）。两次访视时均使用了医学研究委员会问卷、肺功能测定和前鼻测压法。
最初我们检查了3046名受试者。排除慢性阻塞性肺疾病（COPD）患者后，我们重新检查了872名受试者，其中168人患上了COPD（格雷韦纳：24.3%，埃奥雷亚：18.5%）。多变量逻辑回归分析表明，居住地区以及因此暴露于空气污染并非COPD发病的危险因素（比值比：0.51，95%置信区间：0.18 - 1.46，P = 0.21）。另一方面，居住在埃奥雷亚与严重鼻塞的发生密切相关（比值比：11.47，95%置信区间：6.15 - 21.40，P < 0.001）。排除I期COPD患者后以及在从不吸烟者亚组中也发现了类似结果。
空气污染与严重鼻塞有关，但与COPD的发生无关。
