Kilbride H W, Daily D K, Matiu I, Hubbard A M
Department of Pediatrics, University of Missouri-Kansas City Medical School, Children's Mercy Hospital.
J Perinatol. 1989 Dec;9(4):376-81.
The incidence and severity of intracranial hemorrhage (ICH) were determined in a group of surviving infants with birthweights less than 801 g born during the period of 1983 through 1985. Neurodevelopmental status was assessed at 2 and 3 years of age to determine the relationship between neonatal ICH and later outcome in these infants. Forty-four of 77 neonatal survivors (57%) had ICH. Infants with ICH were less mature than those without (25.7 weeks' vs 26.5 weeks' gestation, P less than .05). There were no other perinatal factors that significantly differed between groups. At both 2 and 3 years of age, there were no significant differences between groups of infants with no or mild ICH and those with severe ICH regarding frequency of developmental delay, cerebral palsy, or visual impairment. Persistent ventriculomegaly in infants with ICH was associated with the highest incidence of neurodevelopmental disabilities. For extremely low birthweight infants, the presence and severity of neonatal ICH, in itself, did not adequately predict neurodevelopmental outcome at 2 or 3 years of age. Among infants with ICH, ventriculomegaly persisting to hospital discharge may indicate the greatest risk for neurologic and visual disabilities.
对1983年至1985年期间出生体重低于801克的一组存活婴儿，测定其颅内出血（ICH）的发生率和严重程度。在这些婴儿2岁和3岁时评估神经发育状况，以确定新生儿ICH与后期结局之间的关系。77名新生儿幸存者中有44名（57%）发生了ICH。发生ICH的婴儿比未发生ICH的婴儿成熟度更低（孕周分别为25.7周和26.5周，P<0.05）。两组之间没有其他围产期因素存在显著差异。在2岁和3岁时，无ICH或轻度ICH的婴儿组与重度ICH的婴儿组在发育迟缓、脑瘫或视力障碍的发生率方面没有显著差异。ICH婴儿中持续性脑室扩大与神经发育障碍的发生率最高相关。对于极低出生体重婴儿，新生儿ICH的存在和严重程度本身并不能充分预测其2岁或3岁时的神经发育结局。在发生ICH的婴儿中，持续至出院时的脑室扩大可能表明发生神经和视力残疾的风险最大。
