Koons A H, Mojica N, Jadeja N, Ostfeld B, Hiatt M, Hegyi T
Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, St. Peter's Medical Center, New Brunswick 08903.
Am J Perinatol. 1993 May;10(3):208-11. doi: 10.1055/s-2007-994719.
The neurodevelopmental outcome of premature infants with persistent apnea of prematurity (AOP) is reported. Sixty premature infants (birthweight [BW], 1469 +/- 533 gm; gestational age [GA , 31 +/- 3 weeks) with AOP were compared to 47 control infants (BW, 1586 +/- 581 gm; GA, 31 +/- 3 weeks) matched for gestational age and degree of neonatal illness. The infants were enrolled in a multidisciplinary follow-up program, and outcome data between 12 and 24 months are reported. Assessments included the Bayley Scores of Infant Development, neurologic examinations, speech and hearing examinations. There were no significant differences in the cognitive outcome between the premature infants with AOP and the premature control group. In 50 of 60 infants the Bayley Mental Developmental Index was in the normal range (112 +/- 18) as was 39 of 47 of the control group (112 +/- 13). Delays in motor development were seen in both premature groups, although a greater percentage of premature infants with persistent apnea had mild motor delays than did control infants. There was a comparable incidence of cerebral palsy (8% vs 11%), speech delays (20% vs 23%), retinopathy (8% vs 13%), and esotropia (7% vs 4%) between the infants with AOP and the premature control infants. The presence of persistent neonatal apnea without additional adverse perinatal events did not appear to be associated with a higher incidence of significant developmental problems.
报告了患有持续性早产儿呼吸暂停（AOP）的早产儿的神经发育结局。将60例患有AOP的早产儿（出生体重[BW]，1469±533克；胎龄[GA]，31±3周）与47例胎龄和新生儿疾病程度相匹配的对照婴儿（BW，1586±581克；GA，31±3周）进行比较。这些婴儿参加了一个多学科随访项目，并报告了12至24个月之间的结局数据。评估包括贝利婴儿发育量表评分、神经学检查、言语和听力检查。患有AOP的早产儿与早产对照组在认知结局方面没有显著差异。60例婴儿中有50例的贝利智力发育指数在正常范围内（112±18），对照组47例中有39例（112±13）。两个早产组均出现运动发育延迟，尽管患有持续性呼吸暂停的早产儿出现轻度运动延迟的比例高于对照婴儿。患有AOP的婴儿与早产对照婴儿在脑瘫（8%对11%）、言语延迟（20%对23%）、视网膜病变（8%对13%）和内斜视（7%对4%）的发生率方面相当。持续性新生儿呼吸暂停且无其他围产期不良事件似乎与显著发育问题的较高发生率无关。
