Leemans L
J Pharm Belg. 2013 Sep(3):4-11.
Racecadotril has sufficient proven efficacy in the treatment of acute diarrhea in children. Treatment outcomes in adults are less convincing. The place of gelatin tannate is unclear. Some sources point to potential hepatotoxicity and diminished iron absorption, with a concomitant risk of anemia, at least in case of excessive or prolonged use. Loperamide still has a prominent place in the treatment of acute and chronic diarrhea. Attention should be payed to correct dosing and some well-known contra-indications. Probiotics are indicated in children, as well as in the prevention of antibiotics-induced diarrhea. There is no evidence to support their use in the treatment of acute diarrhea in adults. Up till now publications disagree on the efficacy in the prevention of travelers' diarrhea. Astringents and absorbents are no longer supported in guidelines. Oral rehydration systems have a part to play in pediatric treatment.
消旋卡多曲在治疗儿童急性腹泻方面已证实有足够疗效。在成人中的治疗效果则不那么令人信服。鞣酸蛋白的地位尚不清楚。一些资料指出,至少在过量或长期使用的情况下,它可能有肝毒性并会减少铁的吸收,随之有贫血风险。洛哌丁胺在急性和慢性腹泻治疗中仍占据重要地位。应注意正确给药及一些众所周知的禁忌证。益生菌适用于儿童,也可用于预防抗生素相关性腹泻。没有证据支持其用于治疗成人急性腹泻。到目前为止,关于预防旅行者腹泻的疗效,各出版物观点不一。指南不再支持使用收敛剂和吸附剂。口服补液系统在儿科治疗中发挥着作用。