Moriyoshi Y
Nihon Shokakibyo Gakkai Zasshi. 1989 Oct;86(10):2425-33.
The potentiating effect of secretin on cholecystokinin (CCK)-stimulated exocrine pancreatic secretion was studied in anesthetized rats. Intravenous infusion of CCK-8 in three different doses of 0.03, 0.06 and 0.12 micrograms/kg-hr increased pancreatic secretion of volume, bicarbonate, amylase and trypsin outputs dose-dependently. Simultaneous infusion of CCK-8 with secretin in a dose of 0.03 CU/kg-hr produced statistically greater pancreatic secretion of volume, bicarbonate, amylase and trypsin outputs than that by CCK-8 alone, and than the sum by secretin alone and CCK-8 alone in each dose. Proglumide (600 mg/kg-hr) significantly suppressed exocrine pancreatic secretion produced by CCK-8 (0.06 micrograms/kg-hr) plus secretin (0.03 CU/kg-hr), to the level induced by secretin alone. These results indicate that CCK-8 increased pancreatic secretion dose-dependently, and secretin in a physiological dose potentiates the stimulating effect of CCK-8 on exocrine pancreatic secretion in rats.
在麻醉大鼠中研究了促胰液素对胆囊收缩素（CCK）刺激的胰腺外分泌的增强作用。以0.03、0.06和0.12微克/千克·小时三种不同剂量静脉输注CCK-8，可使胰腺分泌的液体量、碳酸氢盐、淀粉酶和胰蛋白酶产量呈剂量依赖性增加。以0.03 CU/千克·小时的剂量将CCK-8与促胰液素同时输注，在统计学上，其产生的胰腺分泌的液体量、碳酸氢盐、淀粉酶和胰蛋白酶产量比单独使用CCK-8时更高，也高于单独使用促胰液素和各剂量单独使用CCK-8时的总和。丙谷胺（600毫克/千克·小时）显著抑制了由CCK-8（0.06微克/千克·小时）加促胰液素（0.03 CU/千克·小时）产生的胰腺外分泌，使其降至单独使用促胰液素所诱导的水平。这些结果表明，CCK-8可使胰腺分泌呈剂量依赖性增加，生理剂量的促胰液素可增强CCK-8对大鼠胰腺外分泌的刺激作用。
