依诺昔酮对充血性心力衰竭患者的电生理效应。
Electrophysiologic effects of enoximone in patients with congestive heart failure.
作者信息
Hohnloser S H, Zehender M, Geibel A, Meinertz T, Just H
机构信息
Department of Cardiology, University Hospital Freiburg, F.R.G.
出版信息
J Cardiovasc Pharmacol. 1989;14 Suppl 1:S29-32.
The electrophysiologic effects of enoximone were evaluated in 12 patients with idiopathic dilated cardiomyopathy undergoing routine programmed electrical stimulation (PES). Enoximone (1.5 mg/kg for 20 min followed by 0.75 mg/kg for 20 min) significantly shortened the spontaneous sinus cycle length as well as the atrial and ventricular refractory period. Neither during control PES nor during enoximone infusion were sustained ventricular arrhythmias provoked. However, in 5 of 12 patients, there was an increase in the number of repetitive ventricular responses induced by PES during enoximone administration. The observed electrophysiologic changes may be indicators for increased electrical instability of the myocardium in selected patients.
在12例接受常规程控电刺激（PES）的特发性扩张型心肌病患者中评估了依诺昔酮的电生理效应。依诺昔酮（1.5mg/kg持续20分钟，随后0.75mg/kg持续20分钟）显著缩短了自发窦性周期长度以及心房和心室不应期。在对照PES期间和依诺昔酮输注期间均未诱发持续性室性心律失常。然而，在12例患者中的5例中，依诺昔酮给药期间PES诱发的重复性室性反应数量增加。观察到的电生理变化可能是特定患者心肌电不稳定性增加的指标。
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