Jones M E, Helling D K, Rakel R E, Chamberlain M
J Fam Pract. 1978 May;6(5):963-8.
Nasal swabs were obtained from 408 patients seen in a family practice office in an attempt to identify Staphylococcus aureus carriers. Isolated strains were tested for sensitivity to 11 antibiotics. Study participants were interviewed to obtain the following data: age, history of recent hospitalization and/or recent antibiotic use, number of household members, and occupation, if employed in a health-care facility. S aureus was isolated from 109 nasal swabs. This represents a 26.7 percent carrier rate. Only 25.7 percent of the isolates were sensitive to penicillin G and ampicillin. No statistically significant association was found between the patient variables and either the carrier rate or the sensitivity of the S aureus isolates to penicillin. The sensitivity testing demonstrated that 94.5 percent of the isolates were sensitive to tetracycline and erythromycin. Ninety-nine to 100 percent of the isolates were sensitive to all other antibiotics tested. The authors conclude that penicillin G should not be used in the treatment of S aureus infections. Erythromycin, due to demonstrated sensitivity and reasonable cost, is recommended for mild to moderate infections.
从一家家庭医疗诊所的408名患者中采集鼻拭子，试图确定金黄色葡萄球菌携带者。对分离出的菌株进行了11种抗生素的敏感性测试。对研究参与者进行访谈以获取以下数据：年龄、近期住院史和/或近期抗生素使用史、家庭成员数量以及职业（如果受雇于医疗保健机构）。从109份鼻拭子中分离出了金黄色葡萄球菌。这代表了26.7%的携带率。仅25.7%的分离株对青霉素G和氨苄西林敏感。在患者变量与携带率或金黄色葡萄球菌分离株对青霉素的敏感性之间未发现统计学上的显著关联。敏感性测试表明，94.5%的分离株对四环素和红霉素敏感。99%至100%的分离株对所有其他测试抗生素敏感。作者得出结论，青霉素G不应用于治疗金黄色葡萄球菌感染。由于已证明具有敏感性且成本合理，推荐使用红霉素治疗轻度至中度感染。
