非裔美国女性中枢神经系统血清素、空腹血糖与敌意之间的关联。
Associations between central nervous system serotonin, fasting glucose, and hostility in African American females.
作者信息
Boyle Stephen H, Georgiades Anastasia, Brummett Beverly H, Barefoot John C, Siegler Ilene C, Matson Wayne R, Kuhn Cynthia M, Grichnik Katherine, Stafford-Smith Mark, Williams Redford B, Kaddurah-Daouk Rima, Surwit Richard S
机构信息
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, BOX 3366, Durham, NC, 27710, USA,
出版信息
Ann Behav Med. 2015 Feb;49(1):49-57. doi: 10.1007/s12160-014-9626-7.
BACKGROUND
Previous research has shown an association between hostility and fasting glucose in African American women. Central nervous system serotonin activity is implicated both in metabolic processes and in hostility related traits.
PURPOSE
The purpose of this study is to determine whether central nervous system serotonin influences the association between hostility and fasting glucose in African American women.
METHODS
The study consisted of 119 healthy volunteers (36 African American women, 27 White women, 21 White males, and 35 African American males, mean age 34 ± 8.5 years). Serotonin related compounds were measured in cerebrospinal fluid. Hostility was measured by the Cook-Medley Hostility Scale.
RESULTS
Hostility was associated with fasting glucose and central nervous system serotonin related compounds in African American women only. Controlling for the serotonin related compounds significantly reduced the association of hostility to glucose.
CONCLUSIONS
The positive correlation between hostility and fasting glucose in African American women can partly be explained by central nervous system serotonin function.
背景
先前的研究表明，非裔美国女性的敌意与空腹血糖之间存在关联。中枢神经系统血清素活性与代谢过程以及与敌意相关的特质均有关联。
目的
本研究旨在确定中枢神经系统血清素是否会影响非裔美国女性敌意与空腹血糖之间的关联。
方法
该研究由119名健康志愿者组成（36名非裔美国女性、27名白人女性、21名白人男性和35名非裔美国男性，平均年龄34±8.5岁）。在脑脊液中测量血清素相关化合物。通过库克-梅德利敌意量表测量敌意。
结果
仅在非裔美国女性中，敌意与空腹血糖以及中枢神经系统血清素相关化合物有关联。控制血清素相关化合物后，敌意与血糖之间的关联显著降低。
结论
非裔美国女性敌意与空腹血糖之间的正相关关系部分可由中枢神经系统血清素功能来解释。
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