Department of Epidemiology and Biostatistics, Indiana University, Bloomington, IA, USA.
Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IA, USA.
Nutr Res. 2021 May;89:35-44. doi: 10.1016/j.nutres.2021.01.001. Epub 2021 Apr 21.
Hostility is a complex personality trait associated with many cardiovascular risk factor phenotypes. Although magnesium intake has been related to mood and cardio-metabolic disease, its relation with hostility remains unclear. We hypothesize that high total magnesium intake is associated with lower levels of hostility because of its putative antidepressant mechanisms. To test the hypothesis, we prospectively analyzed data in 4,716 young adults aged 18-30 years at baseline (1985-1986) from four U.S. cities over five years of follow-up using data from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Magnesium intake was estimated from a dietary history questionnaire plus supplements at baseline. Levels of hostility were assessed using the Cook-Medley scale at baseline and year 5 (1990-1991). Generalized estimating equations were applied to estimate the association of magnesium intake with hostility as repeated measures at the two time-points (baseline and year 5). General linear model was used to determine the association between magnesium intake and change in hostility over 5 years. After adjustment for socio-demographic and major lifestyle factors, a significant inverse association was observed between magnesium intake and hostility level over 5 years of follow-up. Beta coefficients (95% CI) across higher quintiles of magnesium intake were 0 (reference), -1.28 (-1.92, -0.65), -1.45 (-2.09, -0.81), -1.41 (-2.08, -0.75) and -2.16 (-2.85, -1.47), respectively (P<.01). The inverse association was independent of socio-demographic and major lifestyle factors, supplement use, and depression status at year 5. This prospective study provides evidence that in young adults, high magnesium intake was inversely associated with hostility level independent of socio-demographic and major lifestyle factors.
敌意是一种与许多心血管危险因素表型相关的复杂人格特质。尽管镁的摄入量与情绪和心脏代谢疾病有关，但它与敌意的关系尚不清楚。我们假设，由于其潜在的抗抑郁机制，高总镁摄入量与较低的敌意水平有关。为了检验这一假设，我们前瞻性地分析了来自美国四个城市的 4716 名年龄在 18-30 岁的年轻人的数据，这些人在五年的随访期间（1985-1986 年）参加了冠状动脉风险发展（CARDIA）研究。镁的摄入量是根据基线时的饮食史问卷和补充剂来估计的。敌意水平是使用基线和第 5 年（1990-1991 年）的 Cook-Medley 量表进行评估的。广义估计方程用于估计镁摄入量与两次（基线和第 5 年）重复测量时的敌意之间的关联。线性模型用于确定 5 年内镁摄入量与敌意变化之间的关系。在校正社会人口统计学和主要生活方式因素后，在 5 年的随访中，观察到镁摄入量与敌意水平之间存在显著的负相关。在更高的镁摄入量五分位数中，β系数（95%CI）分别为 0（参考）、-1.28（-1.92，-0.65）、-1.45（-2.09，-0.81）、-1.41（-2.08，-0.75）和-2.16（-2.85，-1.47）（P<.01）。这种负相关独立于社会人口统计学和主要生活方式因素、补充剂使用以及第 5 年的抑郁状况。这项前瞻性研究提供的证据表明，在年轻人中，高镁摄入量与敌意水平呈负相关，独立于社会人口统计学和主要生活方式因素。
