甘氨酸对N-甲基-D-天冬氨酸受体/通道复合物的调节作用。
Glycine modulation of the NMDA receptor/channel complex.
作者信息
Thomson A M
出版信息
Trends Neurosci. 1989 Sep;12(9):349-53. doi: 10.1016/0166-2236(89)90042-8.
PMID:2480676
Abstract
One class of excitatory amino acid (EAA) receptor, the N-methyl-D-aspartate (NMDA) receptor, has excited enormous interest because of its unique pharmacological and physiological properties. Yet another property of this receptor/channel complex has recently emerged: its activation is greatly enhanced by and may even be dependent on, sub-micromolar concentrations of glycine.
摘要
一类兴奋性氨基酸（EAA）受体，即N-甲基-D-天冬氨酸（NMDA）受体，因其独特的药理和生理特性而引发了极大的关注。然而，这种受体/通道复合物最近又展现出了另一种特性：亚微摩尔浓度的甘氨酸能极大地增强其激活作用，甚至可能依赖于甘氨酸。
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