Hendrikx J J M A, Rosing H, Schinkel A H, Schellens J H M, Beijnen J H
Department of Pharmacy & Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Louwesweg 6, PO box 90440, 1006 BK, Amsterdam, The Netherlands.
Bioanalysis. 2014 Apr;6(7):993-1010. doi: 10.4155/bio.14.48.
Since the isolation of paclitaxel and its approval for the treatment of breast cancer, various taxanes and taxane formulations have been developed. To date, almost 100 bioanalytical assays have been published with the method development and optimization often extensively discussed by the authors. This Review presents an overview of assays published between January 1970 and September 2013 that described method development and validation of assays used to quantify taxanes in biological matrices such as plasma, urine, feces and tissue samples. For liquid chromatography assays, sample pretreatment, chromatographic separation and assay performance are compared. Since this Review discusses the limitations of previously developed liquid chromatography assays and gives recommendations for future assay development, it can be used as a reference for future development of liquid chromatography assays for the quantification of taxanes in various biological matrices to support preclinical and clinical studies.
自从紫杉醇被分离出来并被批准用于治疗乳腺癌以来，已经开发了各种紫杉烷类化合物和紫杉烷制剂。迄今为止，已经发表了近100种生物分析方法，作者们经常广泛讨论这些方法的开发和优化。本综述概述了1970年1月至2013年9月期间发表的分析方法，这些方法描述了用于定量生物基质（如血浆、尿液、粪便和组织样本）中紫杉烷类化合物的分析方法的开发和验证。对于液相色谱分析，比较了样品预处理、色谱分离和分析性能。由于本综述讨论了先前开发的液相色谱分析的局限性，并为未来的分析方法开发提供了建议，因此它可作为未来开发用于定量各种生物基质中紫杉烷类化合物的液相色谱分析方法的参考，以支持临床前和临床研究。
