医护人员抗癌药物暴露的高效液相色谱 - 质谱联用尿液检测方法综述。
A review of high performance liquid chromatographic-mass spectrometric urinary methods for anticancer drug exposure of health care workers.
作者信息
Mathias Patricia I, Connor Thomas H, B'Hymer Clayton
机构信息
U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Biomonitoring and Health Assessment Branch, Robert A. Taft Laboratories, 1150 Tusculum Avenue, Cincinnati, OH, 45226, United States.
U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Biomonitoring and Health Assessment Branch, Robert A. Taft Laboratories, 1150 Tusculum Avenue, Cincinnati, OH, 45226, United States.
出版信息
J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Aug 15;1060:316-324. doi: 10.1016/j.jchromb.2017.06.028. Epub 2017 Jun 19.
Abstract
This review describes published high performance liquid chromatography/mass spectrometry (HPLC-MS) methods for the determination of anticancer drugs in human urine as non-invasive tool for monitoring of health care worker exposure to antineoplastic and cytotoxic drugs. HPLC-MS is a sensitive and specific method for analysis of anticancer drugs and their metabolites in biological fluids. In this review, a tabular summary and overview of published HPLC-MS methods are presented, as well as future trends and limitations in this area of research.
摘要
本综述描述了已发表的用于测定人尿中抗癌药物的高效液相色谱/质谱（HPLC-MS）方法，该方法作为一种非侵入性工具，用于监测医护人员接触抗肿瘤和细胞毒性药物的情况。HPLC-MS是分析生物体液中抗癌药物及其代谢物的灵敏且特异的方法。在本综述中，呈现了已发表的HPLC-MS方法的表格总结和概述，以及该研究领域的未来趋势和局限性。
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