• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Inhibition of reverse transcriptases by flavonoids.

作者信息

Spedding G, Ratty A, Middleton E

机构信息

Department of Medicine, State University of New York, Buffalo General Hospital 14203.

出版信息

Antiviral Res. 1989 Sep;12(2):99-110. doi: 10.1016/0166-3542(89)90073-9.

DOI:10.1016/0166-3542(89)90073-9
PMID:2480745
Abstract

Selected naturally occurring flavonoids were shown to inhibit three reverse transcriptases (RT): avian myeloblastosis (AMV) RT, Rous-associated virus-2 (RAV-2) RT and Maloney murine leukemia virus (MMLV) RT when poly (rA)oligo(dT)12-18 or rabbit globin mRNA were used as template. Amentoflavone, scutellarein and quercetin were the most active compounds and their effect was concentration-dependent. The enzymes exhibited differential sensitivity to the inhibitory effects of the flavonoids. The compounds also inhibited rabbit globin mRNA-directed, MMLV RT-catalyzed DNA synthesis. Amentoflavone and scutellarein inhibited ongoing new DNA synthesis catalyzed by RAV-2 RT. Kinetic studies were performed in an attempt to elucidate the mechanism of action of amentoflavone and scutellarein. A model is proposed for the mechanism of action of the flavonoids on RT activity.

摘要

相似文献

1
Inhibition of reverse transcriptases by flavonoids.
Antiviral Res. 1989 Sep;12(2):99-110. doi: 10.1016/0166-3542(89)90073-9.
2
Comparison of the thermal stabilities of reverse transcriptases from avian myeloblastosis virus and Moloney murine leukaemia virus.禽成髓细胞瘤病毒和莫洛尼鼠白血病病毒逆转录酶热稳定性的比较。
J Biochem. 2008 Feb;143(2):261-8. doi: 10.1093/jb/mvm217. Epub 2007 Nov 15.
3
Characterization of Moloney murine leukaemia virus/avian myeloblastosis virus chimeric reverse transcriptases.莫洛尼鼠白血病病毒/禽成髓细胞瘤病毒嵌合逆转录酶的特性分析
J Biochem. 2009 Mar;145(3):315-24. doi: 10.1093/jb/mvn166. Epub 2008 Dec 6.
4
Effects of diterpenes isolated from the Brazilian marine alga Dictyota menstrualis on HIV-1 reverse transcriptase.从巴西海洋藻类月经网翼藻中分离出的二萜类化合物对HIV-1逆转录酶的影响。
Planta Med. 2005 Nov;71(11):1019-24. doi: 10.1055/s-2005-873113.
5
Effects of organic solvents on the reverse transcription reaction catalyzed by reverse transcriptases from avian myeloblastosis virus and Moloney murine leukemia virus.有机溶剂对禽成髓细胞瘤病毒和莫洛尼鼠白血病病毒逆转录酶催化的逆转录反应的影响。
Biosci Biotechnol Biochem. 2010;74(9):1925-30. doi: 10.1271/bbb.100337. Epub 2010 Sep 7.
6
Inhibition mechanisms of HIV-1, Mo-MuLV and AMV reverse transcriptases by Kelletinin A from Buccinulum corneum.角质蝾螺中凯莱亭A对HIV-1、莫洛尼鼠白血病病毒和禽成髓细胞瘤病毒逆转录酶的抑制机制
Experientia. 1996 Aug 15;52(8):812-7. doi: 10.1007/BF01923995.
7
Suramin: a potent inhibitor of the reverse transcriptase of RNA tumor viruses.苏拉明：一种有效的RNA肿瘤病毒逆转录酶抑制剂。
Cancer Lett. 1979 Nov;8(1):9-22. doi: 10.1016/0304-3835(79)90017-x.
8
Polymerization and RNase H activities of the reverse transcriptases from avian myeloblastosis, human immunodeficiency, and Moloney murine leukemia viruses are functionally uncoupled.来自禽成髓细胞瘤病毒、人类免疫缺陷病毒和莫洛尼鼠白血病病毒的逆转录酶的聚合作用和核糖核酸酶H活性在功能上是解偶联的。
J Biol Chem. 1991 Apr 25;266(12):7423-31.
9
Comparative studies of the inhibitory properties of antibiotics on human immunodeficiency virus and avian myeloblastosis virus reverse transcriptases and cellular DNA polymerases.
J Antibiot (Tokyo). 1989 Jan;42(1):107-15. doi: 10.7164/antibiotics.42.107.
10
Inhibition of viral reverse transcriptase by 2',5'-oligoadenylates.2',5'-寡腺苷酸对病毒逆转录酶的抑制作用。
Biochem Biophys Res Commun. 1987 May 29;145(1):291-7. doi: 10.1016/0006-291x(87)91319-2.

引用本文的文献

1
In vitro antiviral effect of ethanolic extracts from Azadirachta indica and Melia azedarach against goat lentivirus in colostrum and milk.印度楝和苦楝树的乙醇提取物对初乳和奶中羊慢病毒的体外抗病毒作用。
Sci Rep. 2023 Mar 22;13(1):4677. doi: 10.1038/s41598-023-31455-5.
2
Protective role of engineered extracellular vesicles loaded quercetin nanoparticles as anti-viral therapy against SARS-CoV-2 infection: A prospective review.载有槲皮素纳米粒的工程细胞外囊泡作为抗 SARS-CoV-2 感染的抗病毒治疗的保护作用：前瞻性综述。
Front Immunol. 2022 Dec 8;13:1040027. doi: 10.3389/fimmu.2022.1040027. eCollection 2022.
3
Natural products can be used in therapeutic management of COVID-19: Probable mechanistic insights.
天然产物可用于治疗 COVID-19：可能的机制见解。
Biomed Pharmacother. 2022 Mar;147:112658. doi: 10.1016/j.biopha.2022.112658. Epub 2022 Jan 20.
4
Quercetin and its derivates as antiviral potentials: A comprehensive review.槲皮素及其衍生物的抗病毒潜力：全面综述。
Phytother Res. 2022 Jan;36(1):266-278. doi: 10.1002/ptr.7309. Epub 2021 Oct 28.
5
Rational design of flavonoid based potential inhibitors targeting SARS-CoV 3CL protease for the treatment of COVID-19.基于黄酮类化合物的潜在抑制剂的合理设计，靶向SARS-CoV 3CL蛋白酶用于治疗COVID-19。
J Mol Struct. 2021 Aug 5;1237:130380. doi: 10.1016/j.molstruc.2021.130380. Epub 2021 Apr 7.
6
Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2.类黄酮作为对抗 SARS-CoV-2 细胞因子风暴的潜在植物疗法。
Phytother Res. 2021 Aug;35(8):4258-4283. doi: 10.1002/ptr.7092. Epub 2021 Mar 30.
7
Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19).槲皮素和维生素 C：预防和治疗 SARS-CoV-2 相关疾病（COVID-19）的实验性协同治疗方法。
Front Immunol. 2020 Jun 19;11:1451. doi: 10.3389/fimmu.2020.01451. eCollection 2020.
8
Anti-Cancer Effect of Quercetin in Xenograft Models with EBV-Associated Human Gastric Carcinoma.槲皮素对EB病毒相关人类胃癌异种移植模型的抗癌作用
Molecules. 2016 Sep 26;21(10):1286. doi: 10.3390/molecules21101286.
9
Quercetin-induced apoptosis prevents EBV infection.槲皮素诱导的细胞凋亡可预防EB病毒感染。
Oncotarget. 2015 May 20;6(14):12603-24. doi: 10.18632/oncotarget.3687.
10
Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives.通过二羟基色酮衍生物研究严重急性呼吸综合征冠状病毒（SARS-CoV）NTP酶/解旋酶的药效团空间。
Bioorg Med Chem Lett. 2009 Aug 15;19(16):4538-41. doi: 10.1016/j.bmcl.2009.07.009. Epub 2009 Jul 9.