Xu Guangfeng, Shi Chunmei, Ji Chenbo, Song Guixian, Chen Ling, Yang Lei, Zhao Yaping, Guo Xirong
Department of Laboratory Medicine, The 82nd Hospital of The People's Liberation Army, Huaian, Jiangsu 223001, P.R. China.
Department of Children Health Care, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Mol Med Rep. 2014 Jul;10(1):223-8. doi: 10.3892/mmr.2014.2204. Epub 2014 May 2.
MicroRNAs (miRNAs) are short non-coding RNAs that are involved in numerous biological processes, including obesity and insulin resistance. miR-26b is an obesity-related intronic miRNA located in the intron of the carboxy‑terminal domain, RNA polymerase II, polypeptide A, small phosphatase 1 gene. miR-26b is abundantly expressed in mice and mature human adipocytes, and is associated with the expression of adipokines. In the present study, the effects of energy-source materials and hormones associated with obesity, on miR-26b expression were investigated. It was demonstrated that free fatty acids (FFAs), glucose, glucocorticoids and growth hormone (GH) downregulate the expression of miR-26b in human adipocytes. The results indicate that the expression of miR-26b is affected by a variety of factors that are correlated with obesity and insulin sensitivity. Therefore, miR-26b may be an important mediator in the development of obesity‑associated insulin resistance.
微小RNA（miRNA）是短链非编码RNA，参与包括肥胖和胰岛素抵抗在内的众多生物学过程。miR-26b是一种与肥胖相关的内含子miRNA，位于羧基末端结构域、RNA聚合酶II、多肽A、小磷酸酶1基因的内含子中。miR-26b在小鼠和成熟人类脂肪细胞中大量表达，并与脂肪因子的表达相关。在本研究中，研究了与肥胖相关的能源物质和激素对miR-26b表达的影响。结果表明，游离脂肪酸（FFA）、葡萄糖、糖皮质激素和生长激素（GH）可下调人类脂肪细胞中miR-26b的表达。结果表明，miR-26b的表达受到多种与肥胖和胰岛素敏感性相关的因素的影响。因此，miR-26b可能是肥胖相关胰岛素抵抗发展过程中的重要介质。
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