Dutta Debaditya, Mahmoud Ahmed M, Leers Steven A, Kim Kang
Center for Ultrasound Molecular Imaging and Therapeutics - Department of Medicine, University of Pittsburgh and UPMC, Pittsburgh, PA, USA ; Heart and Vascular Institute, University of Pittsburgh and UPMC, Pittsburgh, PA, USA.
Center for Ultrasound Molecular Imaging and Therapeutics - Department of Medicine, University of Pittsburgh and UPMC, Pittsburgh, PA, USA ; Heart and Vascular Institute, University of Pittsburgh and UPMC, Pittsburgh, PA, USA ; Department of Biomedical Engineering and Systems, Cairo University, Giza, Egypt.
IEEE Trans Ultrason Ferroelectr Freq Control. 2013 Aug 2;60(8):1660-1668. doi: 10.1109/TUFFc.2013.2748.
Large lipid pools in vulnerable plaques, in principle, can be detected using US based thermal strain imaging (US-TSI). One practical challenge for cardiovascular application of US-TSI is that the thermal strain is masked by the mechanical strain caused by cardiac pulsation. ECG gating is a widely adopted method for cardiac motion compensation, but it is often susceptible to electrical and physiological noise. In this paper, we present an alternative time series analysis approach to separate thermal strain from the mechanical strain without using ECG. The performance and feasibility of the time-series analysis technique was tested numerical simulation as well as water tank experiments using a vessel mimicking phantom and an excised human atherosclerotic artery where the cardiac pulsation is simulated by a pulsatile pump.
原则上，易损斑块中的大脂质池可通过基于超声的热应变成像（US-TSI）检测到。US-TSI在心血管应用中的一个实际挑战是，热应变被心脏搏动引起的机械应变所掩盖。心电图门控是一种广泛采用的心脏运动补偿方法，但它通常易受电噪声和生理噪声的影响。在本文中，我们提出了一种替代的时间序列分析方法，无需使用心电图即可将热应变与机械应变分离。通过数值模拟以及使用模拟血管的模型和切除的人类动脉粥样硬化动脉进行的水箱实验（通过脉动泵模拟心脏搏动），测试了时间序列分析技术的性能和可行性。
