Popescu Claudiu, Bojincă Violeta, Opriş Daniela, Ionescu Ruxandra
"Sfânta Maria" Clinical Hospital, 37-39 Ion Mihalache Boulevard, District 1, 011192 Bucharest, Romania ; Department of Internal Medicine and Rheumatology, "Carol Davila" University of Medicine and Pharmacy, 011192 Bucharest, Romania.
J Osteoporos. 2014;2014:465987. doi: 10.1155/2014/465987. Epub 2014 Apr 8.
Introduction. Atherosclerosis and osteoporosis share an age-independent bidirectional correlation. Rheumatoid arthritis (RA) represents a risk factor for both conditions. Objectives. The study aims to evaluate the connection between the estimated cardiovascular risk (CVR) and the loss of bone tissue in RA patients. Methods. The study has a prospective cross-sectional design and it includes female in-patients with RA or without autoimmune diseases; bone tissue was measured using whole body dual X-ray absorptiometry (wbDXA); CVR was estimated using SCORE charts and PROCAM applications. Results. There were 75 RA women and 66 normal women of similar age. The wbDXA bone indices correlate significantly, negatively, and age-independently with the estimated CVR. The whole body bone percent (wbBP) was a significant predictor of estimated CVR, explaining 26% of SCORE variation along with low density lipoprotein (P < 0.001) and 49.7% of PROCAM variation along with glycemia and menopause duration (P < 0.001). Although obese patients had less bone relative to body composition (wbBP), in terms of quantity their bone content was significantly higher than that of nonobese patients. Conclusions. Female patients with RA and female patients with cardiovascular morbidity have a lower whole body bone percent. Obese female individuals have higher whole body bone mass than nonobese patients.
引言。动脉粥样硬化和骨质疏松存在与年龄无关的双向关联。类风湿关节炎（RA）是这两种病症的一个风险因素。目的。本研究旨在评估类风湿关节炎患者的估计心血管风险（CVR）与骨组织丢失之间的关联。方法。本研究采用前瞻性横断面设计，纳入患有类风湿关节炎或无自身免疫性疾病的女性住院患者；使用全身双能X线吸收法（wbDXA）测量骨组织；使用SCORE图表和PROCAM应用程序估计CVR。结果。有75名类风湿关节炎女性患者和66名年龄相仿的正常女性。wbDXA骨指数与估计的CVR显著、负相关且与年龄无关。全身骨百分比（wbBP）是估计CVR的一个显著预测指标，解释了SCORE变异的26%（与低密度脂蛋白有关，P < 0.001）以及PROCAM变异的49.7%（与血糖和绝经持续时间有关，P < 0.001）。尽管肥胖患者相对于身体成分的骨量较少（wbBP），但就骨量而言，他们的骨含量显著高于非肥胖患者。结论。患有类风湿关节炎的女性患者和有心血管疾病的女性患者全身骨百分比更低。肥胖女性个体的全身骨量高于非肥胖患者。
