Wagan Abrar Ahmed, Haider Syed Nayab, Ahmed Rukhsar, Shafiq Fuad, Nasir Sadia
Dr. Abrar Ahmed Wagan, FCPS. Department of Medicine, Central Park Medical College, Lahore, Pakistan.
Dr. Syed Nayab Haider, MRCP, FRCP. Department of Medicine, Central Park Medical College, Lahore, Pakistan.
Pak J Med Sci. 2017 Jul-Aug;33(4):973-978. doi: 10.12669/pjms.334.12798.
To determine the frequency of modifiable cardiovascular risk factors in Rheumatoid Arthritis patients at tertiary care hospital.
During this study 246 patients of Rheumatoid Arthritis were enrolled from outpatients department of Medicine of Central Park Medical College Hospital, Lahore from July 1, 2016 to January 31, 2017. Demographic data and questions related to study were noted. After 14 hours of fasting 5ml of venous blood was drawn for Cholesterol, triglycerides, HDL and blood sugar level. Blood tests were performed on COBAS c III (ROCHE), Framingham 10 year Risk score was calculated for every individual.
The mean age of male population was (50.2 ±7.5) and females (48.4±7.6) and female gender was common. Seventy eight (78%) of study population has one modifiable risk factor. Most frequent risk factor found in this study was BMI>30 in 48.4% (n=119), High LDL 43.5% (n=107), moderate to high FRS score 40.2% (n=99), Hypertension 37.4% (n=92), Diabetes Mellitus was present in 22.8% (n=56), while smoking was least frequent risk factors with frequency of 15.9% (n=39). Framingham cardiovascular risk score was significantly different, males were having higher mean 10 year risk score (19.7%) and females (8.7%) with (p-<0.01). Regression analysis revealed that older patients of Rheumatoid Arthritis with disease duration of more than seven years are four times more likely to have High Framingham risk score, moderate to high LDL and diabetes mellitus with significant high Odds ratio (p-value <0.05).
Rheumatoid Arthritis patients are having increased chances of developing cardiovascular risk factors leading to cardiovascular events with male sex, increasing age and disease duration.
确定三级医疗机构中类风湿关节炎患者可改变的心血管危险因素的发生率。
在本研究中，2016年7月1日至2017年1月31日期间，从拉合尔中央公园医学院医院内科门诊招募了246例类风湿关节炎患者。记录人口统计学数据和与研究相关的问题。禁食14小时后，抽取5毫升静脉血检测胆固醇、甘油三酯、高密度脂蛋白和血糖水平。在COBAS c III（罗氏）上进行血液检测，为每个人计算弗雷明汉10年风险评分。
男性人群的平均年龄为（50.2±7.5）岁，女性为（48.4±7.6）岁，女性更为常见。78%（n=192）的研究人群有一个可改变的危险因素。本研究中发现最常见的危险因素是BMI>30，占48.4%（n=119）；高LDL，占43.5%（n=107）；中度至高度FRS评分，占40.2%（n=99）；高血压，占37.4%（n=92）；糖尿病，占22.8%（n=56）；而吸烟是最不常见的危险因素，发生率为15.9%（n=39）。弗雷明汉心血管风险评分有显著差异，男性的平均10年风险评分较高（19.7%），女性为（8.7%），（p<0.01）。回归分析显示，类风湿关节炎病程超过7年的老年患者发生高弗雷明汉风险评分、中度至高度LDL和糖尿病的可能性是前者的四倍，优势比显著升高（p值<0.05）。
类风湿关节炎患者发生心血管危险因素并导致心血管事件的几率增加，男性、年龄增长和疾病病程是相关因素。
