Marcos M A, Huetz F, Pereira P, Andreu J L, Martinez-A C, Coutinho A
Unité d'Immunobiologie, Institut Pasteur, Paris, France.
Eur J Immunol. 1989 Nov;19(11):2031-5. doi: 10.1002/eji.1830191110.
Previous observations indicate that "CD5 B lymphocytes" are preferentially clustered in gut-related mesenchymal areas, such as peritoneum, thymus and tonsils. We have now found that pleuropericardial spaces contain an homogeneous population of large-sized, noncycling, nonsecretory B cells, expressing very high levels of surface IgM, little or no IgD, Mac-1 and low levels of B220. This phenotype and the over-representation of some antibody clonotypes suggest that the pleuropericardial cavity contains a pure "CD5 B cell" population. In all mouse strains analyzed, however, many of these cells are CD5-. These findings, together with the common origin of peritoneum and pleural layers in the primitive coelomic cavity, suggest that such B cells differentiate locally from intraembryonic precursors; we propose to designate them as "coelomic", to distinguish them from "stromal", bone marrow-derived B cells.
先前的观察表明，“CD5 B淋巴细胞”优先聚集在与肠道相关的间充质区域，如腹膜、胸腺和扁桃体。我们现在发现，胸膜心包腔中含有一群均匀的、大型的、非循环的、非分泌性的B细胞，它们表达非常高水平的表面IgM、很少或没有IgD、Mac-1以及低水平的B220。这种表型以及某些抗体克隆型的过度表达表明，胸膜心包腔中含有纯的“CD5 B细胞”群体。然而，在所有分析的小鼠品系中，这些细胞中有许多是CD5阴性的。这些发现，连同原始体腔中腹膜和胸膜层的共同起源，表明这些B细胞是从胚胎内前体局部分化而来的；我们建议将它们命名为“体腔B细胞”，以区别于“基质”、骨髓来源的B细胞。
