Electrophysiological expression of endothelin and angiotensin receptors in Xenopus oocytes injected with rat heart mRNA.

作者信息

Lory P, Richard S, Rassendren F A, Tiaho F, Nargeot J

机构信息

Centre de Recherche de Biochimie Macromoléculaire, UPR 8402 CNRS, U249 INSERM, Montpellier, France.

出版信息

FEBS Lett. 1989 Dec 4;258(2):289-92. doi: 10.1016/0014-5793(89)81676-x.

Functional endothelin and angiotensin receptors have been expressed in Xenopus oocyte following the microinjection of rat heart mRNA. Under voltage clamp conditions, application of these peptides clearly induced oscillatory Ca2+-activated chloride currents in a dose-dependent manner. In addition, no direct modulation of expressed or native cardiac Ca channels was observed.