注射大鼠心脏mRNA的非洲爪蟾卵母细胞中内皮素和血管紧张素受体的电生理表达。
Electrophysiological expression of endothelin and angiotensin receptors in Xenopus oocytes injected with rat heart mRNA.
作者信息
Lory P, Richard S, Rassendren F A, Tiaho F, Nargeot J
机构信息
Centre de Recherche de Biochimie Macromoléculaire, UPR 8402 CNRS, U249 INSERM, Montpellier, France.
出版信息
FEBS Lett. 1989 Dec 4;258(2):289-92. doi: 10.1016/0014-5793(89)81676-x.
PMID:2480916
Abstract
Functional endothelin and angiotensin receptors have been expressed in Xenopus oocyte following the microinjection of rat heart mRNA. Under voltage clamp conditions, application of these peptides clearly induced oscillatory Ca2+-activated chloride currents in a dose-dependent manner. In addition, no direct modulation of expressed or native cardiac Ca channels was observed.
摘要
在向非洲爪蟾卵母细胞显微注射大鼠心脏mRNA后，功能性内皮素和血管紧张素受体已在其中得到表达。在电压钳制条件下，应用这些肽可明显以剂量依赖的方式诱导振荡性钙激活氯电流。此外，未观察到对表达的或天然心脏钙通道的直接调节作用。
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