Nobuoka Yu, Tanemura Akihiro, Azumi Yoshinori, Kishiwada Masashi, Osawa Ichiro, Mizuno Shugo, Usui Masanobu, Sakurai Hiroyuki, Tabata Masami, Isaji Shuji
Jpn J Antibiot. 2014 Feb;67(1):15-21.
Doripenem (DRPM) which is injectable carbapenem antimicrobial agent is a compound with high antimicrobial activity against severe acute pancreatitis in carbapenem agents. It does not have a report of the distribution in human pancreatic tissue until now. This time, we performed examination about the distribution in pancreatic tissue of DRPM. Blood and pancreatic tissues were collected from six patients who were administered DRPM intravenously at a dose of 0.5 g after 1 hour from the start of injection. The concentration of DRPM in the serum and pancreatic tissues were measured. The concentrations of DRPM in the pancreatic tissues and serum were 0.58-5.39 microg/g and 0.02-0.24 microg/mL, respectively. DRPM distributed in pancreatic tissues sufficiently, and we could expect that DRPM was useful agent of pancreas infection in acute pancreatitis.
多立培南（DRPM）是一种注射用碳青霉烯类抗菌药物，在碳青霉烯类药物中，它是对重症急性胰腺炎具有高抗菌活性的化合物。到目前为止，尚无其在人体胰腺组织中分布情况的报道。此次，我们对多立培南在胰腺组织中的分布进行了研究。从6例患者身上采集血液和胰腺组织，这些患者在静脉注射0.5 g多立培南1小时后开始给药，注射开始1小时后采集。测量血清和胰腺组织中多立培南的浓度。胰腺组织和血清中多立培南的浓度分别为0.58 - 5.39微克/克和0.02 - 0.24微克/毫升。多立培南在胰腺组织中分布充分，我们可以预期多立培南是急性胰腺炎胰腺感染的有效药物。
