Katrine Verena Wirgenes, MD, Martin Tesli, MD, PhD, NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Elin Inderhaug, BSc, Lavinia Athanasiu, PhD, NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, and Division of Mental Health & Addiction and Department of Medical Genetics, Oslo University Hospital, Oslo, Norway; Ingrid Agartz, MD, PhD, NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo; Division of Mental Health and Addiction, Oslo University Hospital; and Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway; Ingrid Melle, MD, PhD, NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, and Division of Mental Health and Addiction, Oslo University Hospital; Timothy Hughes, PhD, Department of Medical Genetics, Oslo University Hospital; Ole Andreas Andreassen, MD, PhD, NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, and Division of Mental Health and Addiction, Oslo University Hospital; Srdjan Djurovic, PhD, NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, and Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Br J Psychiatry. 2014 Sep;205(3):244-5. doi: 10.1192/bjp.bp.114.145433. Epub 2014 May 8.
ANK3 gene variants have consistently been associated with bipolar spectrum disorder and schizophrenia spectrum disorder. However, the relevance of its encoded protein, ankyrin-3, in these disorders remains elusive. Here, we show that ANK3 gene expression in blood is significantly increased in bipolar disorder and schizophrenia compared with healthy controls. Additionally, we identified potential cis-acting expression quantitative trait loci located close to the transcription start site of one of the isoforms of the gene. These findings suggest that ANK3 mRNA is an interesting marker for further investigation of the underlying mechanisms in psychotic disorders.
ANK3 基因突变与双相情感障碍和精神分裂症谱系障碍密切相关。然而，其编码蛋白锚蛋白-3在这些疾病中的相关性仍然难以捉摸。在这里，我们发现与健康对照组相比，双相情感障碍和精神分裂症患者血液中的 ANK3 基因表达显著增加。此外，我们还确定了位于基因其中一种异构体转录起始位点附近的潜在顺式作用表达数量性状基因座。这些发现表明，ANK3 mRNA 是进一步研究精神疾病潜在机制的一个有趣的标志物。
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