Sherer Benjamin A, Levine Laurence A
Rush University Medical Center, Chicago, Illinois, USA.
Curr Opin Urol. 2014 Jul;24(4):401-6. doi: 10.1097/MOU.0000000000000072.
Although no standard management of erectile dysfunction in prostate cancer (CaP) survivors exists, many treatment options are available. This review summarizes the current understanding of the cause and management of erectile dysfunction in CaP survivors.
Erectile dysfunction after radical therapy for CaP may be more common than previously thought. Genetics and vascular comorbidities may have a significant impact on erectile dysfunction after CaP treatment. Although penile rehabilitation with medical modalities show good efficacy in motivated patients, the return of erectile function is never guaranteed with nonsurgical management. Penile prosthesis placement results in early return to sexual function after CaP treatment with high patient satisfaction rates. Various techniques allow safe placement of a three-piece penile prosthesis in patients with a history of pelvic surgery.
To optimize recovery of erectile function and prevent loss of penile length, penile rehabilitation should be initiated expeditiously after prostatectomy or radiation. In patients with refractory erectile dysfunction, dexterous and motivated patients remain excellent candidates for first and second-line medical therapies. However, early placement of a penile prosthesis following radical prostatectomy is now a proven and viable option.
尽管目前尚无针对前列腺癌(CaP)幸存者勃起功能障碍的标准管理方案,但有多种治疗选择可供选择。本综述总结了目前对CaP幸存者勃起功能障碍病因及管理的认识。
CaP根治性治疗后勃起功能障碍可能比之前认为的更为常见。遗传因素和血管合并症可能对CaP治疗后的勃起功能障碍有重大影响。尽管药物阴茎康复治疗对有积极性的患者显示出良好疗效,但非手术治疗并不能保证勃起功能恢复。阴茎假体植入可使CaP治疗后患者早期恢复性功能,患者满意度高。多种技术可实现为有盆腔手术史的患者安全植入三件式阴茎假体。
为优化勃起功能恢复并防止阴茎长度缩短,前列腺切除术后或放疗后应尽快开始阴茎康复治疗。对于难治性勃起功能障碍患者,灵活且有积极性的患者仍是一线和二线药物治疗的理想人选。然而,根治性前列腺切除术后早期植入阴茎假体现已成为一种经证实且可行的选择。