Bastia Deepak, Zaman Shamsu
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, United States.
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, United States.
Semin Cell Dev Biol. 2014 Jun;30:165-73. doi: 10.1016/j.semcdb.2014.04.030. Epub 2014 May 6.
Replication forks in both prokaryotic and eukaryotic systems pause at random sites due to depletion of dNTP pools, DNA damage, tight binding nonhistone proteins or unusual DNA sequences and/or structures, in a mostly non-polar fashion. However, there is also physiologically programmed replication termination at sequence-specific authentic replication termini. Here, the structure and functions of programmed replication termini, their mechanism of action and their diverse physiological functions in prokaryotes and eukaryotes have been reviewed.
由于脱氧核苷酸三磷酸(dNTP)池的消耗、DNA损伤、紧密结合的非组蛋白或异常的DNA序列和/或结构,原核生物和真核生物系统中的复制叉都会以一种大多非极性的方式在随机位点暂停。然而,在序列特异性的真实复制终点也存在生理程序控制的复制终止。本文综述了程序化复制终点的结构和功能、其作用机制以及它们在原核生物和真核生物中的多种生理功能。