Vielma José Ramón, Bonilla Ernesto, Chacín-Bonilla Leonor, Mora Marylú, Medina-Leendertz Shirley, Bravo Yanauri
Laboratorio de Neurobiología, Centro de Investigaciones Biomédicas, Instituto Venezolano de Investigaciones Científicas (CIB - IVIC), sede Zulia, Maracaibo, Venezuela.
Laboratorio de Neurobiología, Centro de Investigaciones Biomédicas, Instituto Venezolano de Investigaciones Científicas (CIB - IVIC), sede Zulia, Maracaibo, Venezuela; Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia, Maracaibo, estado Zulia, Venezuela.
Acta Trop. 2014 Sep;137:31-8. doi: 10.1016/j.actatropica.2014.04.021. Epub 2014 May 6.
Melatonin, a hormone secreted by the pineal gland, works directly and indirectly as a free radical scavenger. Its other physiological or pharmacological activities could be dependent or independent of receptors located in different cells, organs, and tissues. In addition to its role in promoting sleep and circadian rhythms regulation, it has important immunomodulatory, antioxidant, and neuroprotective effects suggesting that this indole must be considered as a therapeutic alternative against infections. The aim of this review is to describe the effects of melatonin on oxidative stress and the resistance to bacterial (Klebsiella pneumoniae, Helicobacter pylori, Mycobacterium tuberculosis, and Clostridium perfringens), viral (Venezuelan equine encephalomyelitis virus and respiratory syncytial virus), and parasitic (Plasmodium spp., Entamoeba histolytica, Trypanosoma cruzi, Toxoplasma gondii, and Opisthorchis viverrini) infections.
褪黑素是一种由松果体分泌的激素，可直接或间接作为自由基清除剂发挥作用。它的其他生理或药理活性可能依赖或不依赖于位于不同细胞、器官和组织中的受体。除了在促进睡眠和调节昼夜节律方面的作用外，它还具有重要的免疫调节、抗氧化和神经保护作用，这表明这种吲哚必须被视为对抗感染的一种治疗选择。本综述的目的是描述褪黑素对氧化应激以及对细菌（肺炎克雷伯菌、幽门螺杆菌、结核分枝杆菌和产气荚膜梭菌）、病毒（委内瑞拉马脑炎病毒和呼吸道合胞病毒）和寄生虫（疟原虫属、溶组织内阿米巴、克氏锥虫、弓形虫和麝猫后睾吸虫）感染的抵抗力的影响。
