Greco M A, Kamat B R, Demopoulos R I
Department of Pathology, New York University School of Medicine, New York 10016.
Pediatr Pathol. 1989;9(6):679-90. doi: 10.3109/15513818909022375.
Placentas associated with maternal diabetes are generally characterized by features of villous immaturity. We correlated the villous histology with the immunocytochemical distribution of four trophoblastic proteins: beta human chorionic gonadotropin (beta HCG), placental alkaline phosphatase (PLAP), pregnancy specific beta-1-glycoprotein (SP1), and human placental lactogen (HPL) in 14 third-trimester placentas associated with diabetes mellitus. Staining was increased for beta HCG and decreased for PLAP, SP1, and HPL in the diabetic placentas compared to control placentas of similar gestational age. This pattern was most prominent in areas of marked architectural villous immaturity within individual placentas and suggests concomitant functional immaturity.
与母体糖尿病相关的胎盘通常具有绒毛不成熟的特征。我们将14例妊娠晚期与糖尿病相关的胎盘绒毛组织学与四种滋养层蛋白的免疫细胞化学分布进行了关联分析，这四种蛋白分别是β人绒毛膜促性腺激素（β-HCG）、胎盘碱性磷酸酶（PLAP）、妊娠特异性β1-糖蛋白（SP1）和人胎盘催乳素（HPL）。与相似孕周的对照胎盘相比，糖尿病胎盘的β-HCG染色增加，而PLAP、SP1和HPL染色减少。这种模式在单个胎盘内明显的结构绒毛不成熟区域最为突出，提示同时存在功能不成熟。
