Liu Allan Yi, Zheng Hong, Ouyang Gaoliang
State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China.
State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China.
Matrix Biol. 2014 Jul;37:150-6. doi: 10.1016/j.matbio.2014.04.007. Epub 2014 May 9.
The behavior and fate of cells in tissues largely rely upon their cross-talk with the tissue microenvironment including neighboring cells, the extracellular matrix (ECM), and soluble cues from the local and systemic environments. Dysregulation of tissue microenvironment can drive various inflammatory diseases and tumors. The ECM is a crucial component of tissue microenvironment. ECM proteins can not only modulate tissue microenvironment but also regulate the behavior of surrounding cells and the homeostasis of tissues. As a nonstructural ECM protein, periostin is generally present at low levels in most adult tissues; however, periostin is often highly expressed at sites of injury or inflammation and in tumors within adult organisms. Current evidence demonstrates that periostin actively contributes to tissue injury, inflammation, fibrosis and tumor progression. Here, we summarize the roles of periostin in inflammatory and tumor microenvironments.
组织中细胞的行为和命运很大程度上依赖于它们与组织微环境的相互作用，包括相邻细胞、细胞外基质（ECM）以及来自局部和全身环境的可溶性信号。组织微环境的失调可引发各种炎症性疾病和肿瘤。ECM是组织微环境的关键组成部分。ECM蛋白不仅可以调节组织微环境，还能调控周围细胞的行为和组织的稳态。骨膜蛋白作为一种非结构性ECM蛋白，在大多数成年组织中通常含量较低；然而，在成年生物体的损伤或炎症部位以及肿瘤中，骨膜蛋白常常高表达。目前的证据表明，骨膜蛋白在组织损伤、炎症、纤维化和肿瘤进展中发挥着积极作用。在此，我们总结了骨膜蛋白在炎症和肿瘤微环境中的作用。
