Cui Dan, Huang Zhengjie, Liu Yingfu, Ouyang Gaoliang
First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China.
Cell Mol Life Sci. 2017 Dec;74(23):4287-4291. doi: 10.1007/s00018-017-2646-2. Epub 2017 Sep 7.
Tumor microenvironment consists of tumor cells, stromal cells, extracellular matrix and a plethora of soluble components. The complex array of interactions between tumor cells and their surrounding tumor microenvironments contribute to the determination of the fate of tumor cells during tumorigenesis and metastasis. Matricellular protein periostin is generally absent in most adult tissues but is highly expressed in tumor microenvironments. Current evidence reveals that periostin plays a critical role in establishing and remodeling tumor microenvironments such as the metastatic niche, cancer stem cell niche, perivascular niche, pre-metastatic niche, fibrotic microenvironment and bone marrow microenvironment. Here, we summarize the current knowledge of the multifaceted role of periostin in the tumor microenvironments.
肿瘤微环境由肿瘤细胞、基质细胞、细胞外基质和大量可溶性成分组成。肿瘤细胞与其周围肿瘤微环境之间复杂的相互作用有助于在肿瘤发生和转移过程中决定肿瘤细胞的命运。基质细胞蛋白骨膜素在大多数成人组织中通常不存在，但在肿瘤微环境中高度表达。目前的证据表明，骨膜素在建立和重塑肿瘤微环境（如转移龛、癌症干细胞龛、血管周围龛、前转移龛、纤维化微环境和骨髓微环境）中起着关键作用。在此，我们总结了目前关于骨膜素在肿瘤微环境中多方面作用的知识。
