青春期前期的增殖。

Proliferation at the heart of preadolescence.

机构信息

Departments of Pathology, Institute for Stem Cell and Regenerative Medicine, Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA.

Departments of Pathology, Institute for Stem Cell and Regenerative Medicine, Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA; Bioengineering, Institute for Stem Cell and Regenerative Medicine, Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA; Medicine/Cardiology, Institute for Stem Cell and Regenerative Medicine, Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA.

出版信息

Cell. 2014 May 8;157(4):765-7. doi: 10.1016/j.cell.2014.04.025.

DOI:10.1016/j.cell.2014.04.025

PMID:24813600

Abstract

Cardiomyocytes, the cells of the heart muscle, lose nearly all of their proliferative capacity after birth, limiting the heart's ability to regenerate. Naqvi et al. now identify a transient burst of cardiomyocyte proliferation during preadolescence, driven by a thyroid hormone surge, with therapeutic implications for congenital and acquired heart diseases.

摘要

心肌细胞是心脏肌肉的细胞，出生后几乎失去了所有的增殖能力，限制了心脏的再生能力。Naqvi 等人现在发现，在青春期前，甲状腺激素激增会引发心肌细胞的短暂增殖，这对先天性和后天性心脏病具有治疗意义。