Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Harvard Stem Cell Institute and Harvard University Department of Stem Cell and Regenerative Biology, 7 Divinity Avenue, Cambridge, MA 02138, USA.
Cell. 2014 May 8;157(4):769-70. doi: 10.1016/j.cell.2014.04.014.
Although stem cells are subject to niche control, evidence is emerging that they also contribute to generating the niche through their offspring. Using the hair follicle as a model, Hsu at al. demonstrate that the transient-amplifying cells, downstream of stem cells and well-known cell producers, signal back to stem cells to maintain long-term regenerative capacity.
尽管干细胞受到龛位控制，但有证据表明，它们也通过其后代为龛位的形成做出贡献。Hsu 等人利用毛囊作为模型，证明了短暂扩增细胞（位于干细胞和已知的细胞产生细胞下游）向干细胞发出信号，以维持长期的再生能力。
