de Vries Paul S, Gielen Marij, Rizopoulos Dimitris, Rump Patrick, Godschalk Roger, Hornstra Gerard, Zeegers Maurice P
Department of Epidemiology, Erasmus Medical Center, the Netherlands; NUTRIM School for Nutrition, Toxicology and Metabolism, Departments of Complex Genetics, Cluster of Genetics and Cell Biology, Maastricht University, the Netherlands.
NUTRIM School for Nutrition, Toxicology and Metabolism, Departments of Complex Genetics, Cluster of Genetics and Cell Biology, Maastricht University, the Netherlands.
Prostaglandins Leukot Essent Fatty Acids. 2014 Sep;91(3):81-5. doi: 10.1016/j.plefa.2014.04.002. Epub 2014 Apr 25.
Prenatal polyunsaturated fatty acid (PUFA) concentrations may be involved in the prenatal programming of adiposity. In this study we therefore explored the association between maternal PUFA concentrations, measured up to four times during pregnancy, and offspring adiposity at age 7 in 234 mother-child pairs of the Maastricht Essential Fatty Acid Birth cohort. Only dihomo-gamma-linolenic acid (DGLA, an n-6 fatty acid) concentration was associated with adiposity: per standard deviation increase in relative DGLA concentration, BMI increased by 0.44kg/m(2) (CI95: 0.16, 0.72), sum of skinfolds increased by 3.41mm (CI95: 1.88, 4.95), waist circumference increased by 1.09cm (CI95: 0.40, 1.78), and plasma leptin concentration increased by 0.66µg/l (CI95: 0.20, 1.11). In conclusion, maternal DGLA throughout gestation was associated with increased BMI and some additional measures of adiposity at age 7. This suggests that maternal DGLA might play a role in or reflect the prenatal programming of adiposity.
产前多不饱和脂肪酸（PUFA）浓度可能与肥胖的产前编程有关。因此，在本研究中，我们在马斯特里赫特必需脂肪酸出生队列的234对母婴中，探讨了孕期测量多达四次的母体PUFA浓度与后代7岁时肥胖之间的关联。只有二高-γ-亚麻酸（DGLA，一种n-6脂肪酸）浓度与肥胖有关：相对DGLA浓度每增加一个标准差，BMI增加0.44kg/m²（95%置信区间：0.16，0.72），皮褶厚度总和增加3.41mm（95%置信区间：1.88，4.95），腰围增加1.09cm（95%置信区间：0.40，1.78），血浆瘦素浓度增加0.66µg/l（95%置信区间：0.20，1.11）。总之，整个孕期母体DGLA与7岁时BMI升高及一些额外的肥胖指标有关。这表明母体DGLA可能在肥胖的产前编程中起作用或反映了肥胖的产前编程。
