双石蒜裂环醚 A 的全合成。

Total synthesis of biselyngbyolide A.

机构信息

Department of Chemistry, Faculty of Science and Technology, Keio University , Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan.

出版信息

Org Lett. 2014 Jun 6;16(11):2858-61. doi: 10.1021/ol500996n. Epub 2014 May 9.

DOI:10.1021/ol500996n

PMID:24815005

Abstract

Biselyngbyolide A is an 18-membered macrolide that exhibits significant biological activities such as growth-inhibitory activity and apoptosis inducing activity against cancer cells. In this study, the first total synthesis of biselyngbyolide A by using an intramolecular Stille coupling reaction as a key step is achieved.

摘要

比西灵波内酯 A 是一个 18 元大环内酯，具有显著的生物活性，如对癌细胞的生长抑制活性和凋亡诱导活性。在本研究中，首次通过使用分子内 Stille 偶联反应作为关键步骤实现了比西灵波内酯 A 的全合成。