Hou Ruixia, Liu Ruifeng, Niu Xuping, Chang Wenjuan, Yan Xin, Wang Chunfang, Li Junqin, An Peng, Li Xinhua, Yin Guohua, Zhang Kaiming
Institute of Dermatology, Taiyuan City Central Hospital, Taiyuan, China.
Exp Dermatol. 2014 Jul;23(7):521-3. doi: 10.1111/exd.12446.
Mesenchymal stem cells (MSCs) have immunoregulatory and proangiogenic effects and are suggested to be involved in the pathological processes of immune-related diseases, including psoriasis. Biological characteristics of bone marrow MSCs (BMSCs) from patients with autoimmune diseases, such as systemic lupus erythematosus or rheumatoid arthritis, but not psoriasis, have been characterized. We compared the gene expression profile and biological characteristics of BMSCs from patients with psoriasis and healthy controls. Although the phenotype, differentiation potential and ability to support CD34(+) cell proliferation were similar to those of normal BMSCs, psoriatic BMSCs showed aberrant proliferative activity, increased apoptosis rate and a characteristic gene expression profile. These aberrations may develop after the abnormal immune response in psoriasis and result in BMSC dysfunction. The functionally deficient BMSCs may then fail to suppress overactive immune cells, thereby contributing to the pathogenesis of psoriasis.
间充质干细胞（MSCs）具有免疫调节和促血管生成作用，提示其参与包括银屑病在内的免疫相关疾病的病理过程。自身免疫性疾病患者（如系统性红斑狼疮或类风湿关节炎患者，而非银屑病患者）骨髓间充质干细胞（BMSCs）的生物学特性已得到表征。我们比较了银屑病患者和健康对照者BMSCs的基因表达谱和生物学特性。尽管银屑病患者BMSCs的表型、分化潜能及支持CD34(+)细胞增殖的能力与正常BMSCs相似，但前者显示出异常的增殖活性、凋亡率增加及特征性基因表达谱。这些异常可能在银屑病异常免疫反应后出现，并导致BMSCs功能障碍。功能缺陷的BMSCs随后可能无法抑制过度活跃的免疫细胞，从而促进银屑病的发病机制。
