Hébert-Lalonde Noémie, Carmant Lionel, Safi Dima, Roy Marie-Sylvie, Lassonde Maryse, Saint-Amour Dave
Département de psychologie, Université de Montréal, Montréal, QC, Canada.
Doc Ophthalmol. 2014 Aug;129(1):17-26. doi: 10.1007/s10633-014-9439-9. Epub 2014 May 10.
The aim of this study was to develop a fast and efficient electrophysiological protocol to examine the visual field's integrity, which would be useful in pediatric testing.
Steady-state visual-evoked potentials (ssVEPs) to field-specific radial checkerboards flickering at two cycle frequencies (7.5 and 6 Hz for central and peripheral stimulations, respectively) recorded at Oz were collected from 22 participants from 5 to 34 years old and from 5 visually impaired adolescents (12-16 years old). Responses from additional leads (POz, O1, O2), and the impact of gaze deviation on the signals, were also investigated in a subgroup of participants.
Steady-state visual-evoked potentials responses were similar at all electrode sites, although the signal from the central stimulation was significantly higher at Oz and was highly sensitive in detecting gaze deviation. No effect of age or sex was found, indicating similar ssVEP responses between adults and healthy children. Visual acuity was related to the central signal when comparing healthy participants with four central visual impaired adolescents. Clinical validation of our electrophysiological protocol was also achieved in a 15-year-old adolescent with a severe peripheral visual deficit, as assessed with Goldmann perimetry.
A single electrode over Oz is sufficient to gather both central and peripheral visual signals and also to control for gaze deviation. Our method presents several advantages in evaluating visual fields integrity, as it is fast, reliable, and efficient, and applicable in children as young as 5 years old. However, a larger sample of healthy children should be tested to establish clinical norms.
本研究的目的是开发一种快速有效的电生理方案，以检测视野的完整性，这在儿科测试中会很有用。
从22名年龄在5至34岁的参与者以及5名视力受损青少年（12至16岁）中收集在Oz处记录的对特定视野的径向棋盘格以两种循环频率（分别为中央和周边刺激的7.5和6 Hz）闪烁的稳态视觉诱发电位（ssVEP）。还在一部分参与者中研究了来自其他导联（POz、O1、O2）的反应以及注视偏差对信号的影响。
尽管来自中央刺激的信号在Oz处明显更高且在检测注视偏差方面高度敏感，但在所有电极部位的稳态视觉诱发电位反应相似。未发现年龄或性别的影响，表明成人和健康儿童的ssVEP反应相似。在将健康参与者与四名中央视力受损青少年进行比较时，视力与中央信号相关。正如用戈德曼视野计评估的那样，我们的电生理方案在一名患有严重周边视力缺陷的15岁青少年中也实现了临床验证。
Oz上方的单个电极足以收集中央和周边视觉信号，也足以控制注视偏差。我们的方法在评估视野完整性方面具有几个优点，因为它快速、可靠且高效，并且适用于年仅5岁的儿童。然而，应该测试更大样本的健康儿童以建立临床规范。
