[人类与动物流感病毒之间的抗原-基因联系]

[Antigenic-genetic connections between human and animal influenza viruses].

作者信息

Rovnova Z I, Isaeva E I, Platonova A L, Kosiakov P N

出版信息

Vopr Virusol. 1989 Sep-Oct;34(5):553-7.

PMID:2481903

Abstract

A comparative immunological analysis of the composition of antigenic determinants (AGD) in hemagglutinins of human influenza A virus (HIAV) of the serosubtypes H1, H2, H3, and in hemagglutinins of animal influenza viruses (AIV) of the serosubtypes H1, H3-H6, H8-H11 with 25 polyclonal highly active sera was demonstrated. Using original monospecific mon AGD in HIAV and AIV hemagglutinins was demonstrated. Using original monospecific antibodies to individual AGD, those AGD contributing to similarity and differences between HIAV and AIV were determined. It was found that influenza A. virus strains isolated from man in the USSR in 1986 were identical in the antigenic structure of hemagglutinin with that isolated from a tern in 1973 (A/tern/Turkmenistan/18/73).

摘要

对血清亚型H1、H2、H3的人流感A病毒（HIAV）血凝素以及血清亚型H1、H3 - H6、H8 - H11的动物流感病毒（AIV）血凝素中的抗原决定簇（AGD）组成进行了比较免疫学分析，使用了25种多克隆高活性血清。证明了在HIAV和AIV血凝素中使用原始单特异性单AGD。使用针对单个AGD的原始单特异性抗体，确定了那些导致HIAV和AIV之间相似性和差异的AGD。发现1986年在苏联从人类分离出的甲型流感病毒株在血凝素的抗原结构上与1973年从一只燕鸥分离出的病毒株（A/燕鸥/土库曼斯坦/18/73）相同。