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从动物中分离出的流感病毒中的人流感病毒抗原决定簇

[Antigenic determinants of human influenza viruses among the influenza viruses isolated from animals].

作者信息

Isaeva E I, Belkina T S, Rovnova Z I, Kosiakov P N, Selivanov Ia M

出版信息

Vopr Virusol. 1982 Nov-Dec;27(6):681-6.

PMID:6186090
Abstract

Comparative studies of the antigenic properties of hemagglutinin (HA) of animal and human viruses revealed both similarities between them and complete differences in the composition of antigenic determinants. Avian influenza viruses A/chicken/Kamchatka/12/71, A/pintail/Primorie/730/76, and A/bat/Alma-Ata/73/77 were completely identical with human strains of influenza virus. Influenza A/horse/Miami/63 contains one antigenic determinant H3.1.HA of A/tern/Turkmenia/18/73 (Hav7) viruses has a peculiar set of antigens. Apart from two antigenic determinants H3.1 and H3.3 inherent in human virus strains, HA of A/tern/Turkmenia/18/73 virus contains an antigenic determinant the population of antibodies to which shows no relation to HA of subtypes Hav2-Hav9.

摘要

对动物和人类病毒血凝素(HA)抗原特性的比较研究表明,它们之间既有相似之处,抗原决定簇的组成也存在完全差异。禽流感病毒A/鸡/堪察加半岛/12/71、A/针尾鸭/滨海边疆区/730/76和A/蝙蝠/阿拉木图/73/77与人类流感病毒株完全相同。甲型流感病毒A/马/迈阿密/63含有一个抗原决定簇H3.1。A/燕鸥/土库曼斯坦/18/73(Hav7)病毒的HA具有一组独特的抗原。除了人类病毒株所固有的两个抗原决定簇H3.1和H3.3外,A/燕鸥/土库曼斯坦/18/73病毒的HA还含有一个抗原决定簇,针对该抗原决定簇的抗体群体与Hav2 - Hav9亚型的HA没有关系。

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