[慢性鼻窦炎骨炎相关因素的临床分析]

[Clinical analysis of the correlation factors of chronic sinusitis osteitis].

作者信息

Cheng Lei, Huang Zhenxiao, Huang Qian, Wang Chengshuo, Cui Shunjiu, Lin Feng, Sun Yan, Zhou Bing

机构信息

Department of Otorhinolaryngology Head and Neck Surgery,Daxing Hospial, Capital Medical University,Beijing 102600, China.

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education (Capital Medical University), Beijing 100730, China. Email:

出版信息

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Mar;49(3):205-9.

PMID:24820489

Abstract

OBJECTIVE

To analyse the severity of chronic sinusitis osteitis and the correlation factors by global osteitis scoring scale(GOSS).

METHODS

Three hundreds and thirty-four patients with chronic rhinosinusitis with or without nasal polyps(CRSwNP/CRSsNP) were enrolled prospectively in a large tertiary referral center. Preoperative sinus CT was analysed by PHILIPS MxLiteView software.Using grading and classification of GOSS, the association between GOSS and gender, age, smoking, CRS course, asthma, skin prick test(SPT), aspirin sensitive asthma (ASA), nasal polyp, Lund-Mackay, Lund-Kennedy, the number of previous sinus surgeries was examined.Finally a marker factors of severity of CRS osteitis was concluded.

RESULTS

There was no association between CRS osteitis and gender(P = 0.542), age(P = 0.092), smoking(P = 0.695), SPT(P = 0.182). Multiple liner regression analysis showed that there was no association between CRS osteitis and nasal polyps, ASA and asthma (all P > 0.05). The severity of CRS osteitis was correlated with the number of previous sinus surgeries, Lund-Mackay scores, Lund-Kennedy scores, CRS course (r1 = 0.528, r2 = 0.170, r3 = 0.193, r4 = 0.146, respectively, all P < 0.01).

CONCLUSIONS

Osteitis is an important reason of refractory chronic rhinosinusitis. The number of previous sinus surgeries can be used as an important marker for the severity of the osteitis.

摘要

目的

采用整体骨炎评分量表（GOSS）分析慢性鼻窦炎骨炎的严重程度及相关因素。

方法

前瞻性纳入一家大型三级转诊中心的334例伴有或不伴有鼻息肉的慢性鼻-鼻窦炎（CRSwNP/CRSsNP）患者。术前鼻窦CT采用飞利浦MxLiteView软件进行分析。运用GOSS分级和分类，研究GOSS与性别、年龄、吸烟、CRS病程、哮喘、皮肤点刺试验（SPT）、阿司匹林敏感性哮喘（ASA）、鼻息肉、Lund-Mackay评分、Lund-Kennedy评分、既往鼻窦手术次数之间的关联。最终得出CRS骨炎严重程度的标志物因素。

结果

CRS骨炎与性别（P = 0.542）、年龄（P = 0.092）、吸烟（P = 0.695）、SPT（P = 0.182）之间无关联。多元线性回归分析显示，CRS骨炎与鼻息肉、ASA和哮喘之间均无关联（均P > 0.05）。CRS骨炎的严重程度与既往鼻窦手术次数、Lund-Mackay评分、Lund-Kennedy评分、CRS病程相关（r1 = 0.528，r2 = 0.170，r3 = 0.193，r4 = 0.146，均P < 0.01）。