Mao Mingfeng, Wang Rongguang, Wang Hongtian, Zhang Xinxin, Chen Lei
Department of Otorhinolaryngology Head Neck Surgery, People Liberation Army General Hospital, Beijing 100853, China.
Department of Otorhinolaryngology Head Neck Surgery, People Liberation Army General Hospital, Beijing 100853, China. Email:
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Mar;49(3):210-3.
To investigate the optimal treatment and prognostic factors of esthesioneuroblastoma (ENB).
Forty-nine cases of ENB, received therapies in Chinese people liberation army general hospital from October 2004 to June 2013, were reviewed retrospectively. The therapeutical strategies and prognostic factors were analyzed using the Kaplan-Meier method. Efficacy of different therapeutical strategies was compared.
The 5-year overall survival (OS) in the group was 63.8%. The 5-year OS of Kadish stage A, B, C were 90.0%, 77.1%, 32.6%, respectively, with significant difference (χ(2) = 7.379, P = 0.03). The 5-year OS of the patients treated by surgery and radiotherapy, chemoradiotherapy, surgery with chemoradiotherapy were 68.6%, 0, 92.3%, respectively, with significant difference (χ(2) = 8.140, P = 0.02). The 5-year OS of the patients with transnasal endoscopic resection (or combined with transcranial resection) and lateral rhinotomy ( or combined with transcranial resection) were 63.7%, 50.0%, respectively, which had no significant difference (χ(2) = 3.818, P = 0.05).
ENB has a relatively good prognosis in head and neck malignancies, the prognosis is associated with clinical stages and treatment approaches. Transnasal endoscopic surgery based multimodality is the preferable choice.
探讨嗅神经母细胞瘤（ENB）的最佳治疗方法及预后因素。
回顾性分析2004年10月至2013年6月在中国人民解放军总医院接受治疗的49例ENB患者。采用Kaplan-Meier法分析治疗策略及预后因素，并比较不同治疗策略的疗效。
该组患者5年总生存率（OS）为63.8%。Kadish A、B、C期患者的5年OS分别为90.0%、77.1%、32.6%，差异有统计学意义（χ(2)=7.379，P=0.03）。接受手术加放疗、放化疗、手术加放化疗的患者5年OS分别为68.6%、0、92.3%，差异有统计学意义（χ(2)=8.140，P=0.02）。经鼻内镜切除术（或联合经颅切除术）和鼻侧切开术（或联合经颅切除术）患者的5年OS分别为63.7%、50.0%，差异无统计学意义（χ(2)=3.818，P=0.05）。
ENB在头颈部恶性肿瘤中预后相对较好，预后与临床分期及治疗方法有关。基于经鼻内镜手术的多模式治疗是首选。
