Balakirski G, Hölzle F, Megahed M
Klinik für Dermatologie und Allergologie, Universitätsklinikum der RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland,
Hautarzt. 2014 May;65(5):390-2. doi: 10.1007/s00105-014-2790-7.
About 5 % of all malignant tumors affect oral cavity. With a share of 95% squamous cell carcinoma is the most common type of the malignant tumors of oral mucosa.
In our case the patient developed a squamous cell carcinoma of buccal mucosa about 2 years after excision of verrucous leukoplakia with epithelial dysplasia at the same location. Although chronic alcohol abuse, tobacco use and infection with HPV 16 are the most important risk factors for development of squamous cell carcinoma of the oral cavity, our patient had none of these risk factors. We treated the patient in accordance with current guidelines by complete excision of the tumor as well as an elective neck dissection of the ipsilateral side. Untill the present time the patient is free of recurrence.
Although rare, squamous cell carcinoma of oral mucosa may also occur in patients that have no risk factors for it. Therefore, every dental and medical examination in each patient should include an inspection of the entire oral mucosa.
约5%的所有恶性肿瘤发生于口腔。鳞状细胞癌占口腔黏膜恶性肿瘤的95%，是最常见的类型。
在我们的病例中，患者在同一部位切除伴有上皮发育异常的疣状白斑约2年后，发生了颊黏膜鳞状细胞癌。尽管长期酗酒、吸烟和感染人乳头瘤病毒16型是口腔鳞状细胞癌发生的最重要危险因素，但我们的患者没有这些危险因素。我们按照现行指南对患者进行了治疗，完整切除肿瘤并对同侧进行了选择性颈清扫术。截至目前，患者无复发。
尽管罕见，但口腔黏膜鳞状细胞癌也可能发生在没有危险因素的患者中。因此，对每位患者的每次牙科和医学检查都应包括对整个口腔黏膜的检查。
